[1] Niigata Univ, Niigata, Japan
[2] Aichi Med Univ, Aichi, Japan
[3] Osaka Univ, Osaka, Japan
[4] Kyoto Prefectural Univ Med, Kyoto, Japan
[5] Int Univ Hlth & Welf, Atami Hosp, Shizuoka, Japan
[6] Novartis Pharma AG, Basel, Switzerland
[7] Jichi Med Univ, Shimotsuke, Tochigi, Japan