Cytotoxic and antioxidant constituents from Garcinia subelliptica

被引：33

作者：

Lin, Kai-Wei ^{[1
]}

Huang, A-Mei ^{[2
]}

Yang, Shyh-Chyun ^{[1
]}

Weng, Jing-Ru ^{[3
]}

Hour, Tzyh-Chyuan ^{[2
]}

Pu, Yeong-Shiau ^{[4
]}

Lin, Chun-Nan ^{[3
,5
]}

机构：

[1] Kaohsiung Med Univ, Fac Pharm, Coll Pharm, Kaohsiung 80708, Taiwan

[2] Kaohsiung Med Univ, Inst Biochem, Coll Med, Kaohsiung 80708, Taiwan

[3] China Med Univ, Sch Med, Dept Biol Sci & Technol, Taichung 40402, Taiwan

[4] Natl Taiwan Univ, Dept Urol, Coll Med, Taipei 10002, Taiwan

[5] Kaohsiung Med Univ, Fac Fragrance & Cosmet, Coll Pharm, Kaohsiung 80708, Taiwan

来源：

FOOD CHEMISTRY | 2012年 / 135卷 / 02期

关键词：

Triterpenoid; Phloroglucinol; Cyrotoxity; Antioxidant; Garcinia subelliptica; XANTHINE-OXIDASE; TRANSITIONAL CARCINOMA; TERPENOIDS; PHLOROGLUCINOLS; DERIVATIVES;

D O I：

10.1016/j.foodchem.2012.04.133

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new triterpenoids, garcinielliptones Q(1) and S (3), and a new phloroglucinol, garcinielliptone R (2), were isolated from the seed of Garcinia subelliptica. Their structures were established by analysis of their spectroscopic data. Phloroglucinol, garcinielliptone FC (4) from this plant exhibited a significant increase of antiproliferative effect, while 4 combined with cisplatin significantly caused decrease of cell inhibition induced by cisplatin in NTUB1. Exposure of NTUB1 cells to 4 cotreated with cisplatin for significantly decreased the amount of reactive oxygen species (ROS) than that of the total amount generated by 4 and cisplatin. These results suggested that 4 could protect the cisplatin toxicity through reduction of ROS in NTUB1. Phloroglucinols, garcinielliptones, A (5) and F (7), and garsubelline A (6), from this plant, revealed ABTS radical cation scavenging activity and 5 displayed an inhibitory effect on xanthine oxidase. These finding showed that 5-7 may be used as antioxidants. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：851 / 859

页数：9

共 27 条

[1] Further study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agents [J].

Bunyathaworn, Potjamarn ;

Boonananwong, Suthinee ;

Kongkathip, Boonsong ;

Kongkathip, Ngampong .

STEROIDS, 2010, 75 (06) :432-444

[2] Terpenoids Induce Cell Cycle Arrest and Apoptosis from the Stems of Celastrus kusanoi Associated with Reactive Oxygen Species [J].

Chen, Hui-Ling ;

Lin, Kai-Wei ;

Huang, A-Mei ;

Tu, Huang-Yao ;

Wei, Bai-Luh ;

Hour, Tzyh-Chyuan ;

Yen, Ming-Hong ;

Pu, Yeong-Shiou ;

Lin, Chun-Nan .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (06) :3808-3812

[3] CONSTITUENTS OF THE LATEX OF EUPHORBIA-ANTIQUORUM [J].

GEWALI, MB ;

HATTORI, M ;

TEZUKA, Y ;

KIKUCHI, T ;

NAMBA, T .

PHYTOCHEMISTRY, 1990, 29 (05) :1625-1628

[4] Antioxidants from a Chinese medicinal herb -: Lithospermum erythrorhizon [J].

Han, He ;

Weng, Xinchu ;

Bi, Kaishun .

FOOD CHEMISTRY, 2008, 106 (01) :2-10

[5] Role of reactive oxygen species in cell signalling pathways [J].

Hancock, JT ;

Desikan, R ;

Neill, SJ .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2001, 29 :345-350

[6]

Hour TC, 2000, ANTICANCER RES, V20, P3221

[7] Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability [J].

Huang, AM ;

Montagna, C ;

Sharan, S ;

Ni, YJ ;

Ried, T ;

Sterneck, E .

ONCOGENE, 2004, 23 (08) :1549-1557

[8] The chemistry behind antioxidant capacity assays [J].

Huang, DJ ;

Ou, BX ;

Prior, RL .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (06) :1841-1856

[9] Antioxidant abietane diterpenoids from Salvia barrelieri [J].

Kabouche, Ahmed ;

Kabouche, Zahia ;

Ozturk, Mehmet ;

Kolak, Ufuk ;

Topcu, Gulacti .

FOOD CHEMISTRY, 2007, 102 (04) :1281-1287

[10] Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids [J].

Katona, Bryson W. ;

Cummins, Carolyn L. ;

Ferguson, Andrew D. ;

Li, Tingting ;

Schmidt, Daniel R. ;

Mangelsdorf, David J. ;

Covey, Douglas F. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (24) :6048-6058

← 1 2 3 →