A Review on Camptothecin Analogs with Promising Cytotoxic Profile

被引：20

作者：

Amin, Sk Abdul ^{[1
,2
]}

Adhikari, Nilanjan ^{[1
]}

Jha, Tarun ^{[1
]}

Gayen, Shovanlal ^{[2
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Div Med & Pharmaceut Chem, Nat Sci Lab, POB 17020, Kolkata 700032, W Bengal, India

[2] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Lab Drug Design & Discovery, Sagar 470003, Madhya Pradesh, India

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 13期

关键词：

Camptothecin; homocamptothecin; topoisomerase; cytotoxicity; cancer cell lines; structure-activity relationship; quantitative structure-activity relationship; IN-VITRO CYTOTOXICITY; PLANT ANTITUMOR AGENTS; DNA TOPOISOMERASE-II; C-RING ANALOGS; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; PHYSIOLOGICAL PH; CANCER CELLS; DERIVATIVES; 20(S)-CAMPTOTHECIN;

D O I：

10.2174/1871520618666180327140956

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic agent acting against a variety of cancer cell lines. Though searches have been continued for last six decades, still it is a demanding task to design potent and cytotoxic CPTs. Different CPT analogs are synthesized to enhance the cytotoxic potential as well as to increase the pharmacokinetic properties of these analogs. Some of these analogs were proven to be clinically effective in different cancer cell lines. In this article, different CPT analogs have been highlighted extensively to get a detail insight about the structure-property relationships as well as different quantitative structure-activity relationships (QSARs) modeling of these analogs are also discussed. This study may be beneficial for designing newer CPT analogs in future.

引用

页码：1796 / 1814

页数：19

共 96 条

[21] Purification and characterization of human DNA topoisomerase IIIα [J].

Goulaouic, H ;

Roulon, T ;

Flamand, O ;

Grondard, L ;

Lavelle, F ;

Riou, JF .

NUCLEIC ACIDS RESEARCH, 1999, 27 (12) :2443-2450

[22]

GOVINDACHARI TR, 1972, PHYTOCHEMISTRY, V2, P3529

[23] PLANT ANTI-CANCER AGENTS .10. ISOLATION OF CAMPTOTHECIN AND 9-METHOXYCAMPTOTHECIN FROM ERVATAMIA-HEYNEANA [J].

GUNASEKERA, SP ;

BADAWI, MM ;

CORDELL, GA ;

FARNSWORTH, NR ;

CHITNIS, M .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (05) :475-477

[24] Synthesis and Biological Assays of 9-(Acylamino)homocamptothecins as DNA Topoisomerase I Inhibitors [J].

Guo, Wei ;

Dong, Guoqiang ;

Zhu, Lingjian ;

Liu, Wenfeng ;

Zhuang, Chunlin ;

Guo, Zizhao ;

Yao, Jianzhong ;

Sheng, Chunquan ;

Zhang, Huojun ;

Miao, Zhenyuan ;

Zhang, Wannian .

CHEMISTRY & BIODIVERSITY, 2013, 10 (10) :1804-1815

[25]

Hajian R., 2013, J. Spectrosc, V2013, P1

[26] 20-(S)-camptothecin analogues as DNA topoisomerase I inhibitors: A QSAR study [J].

Hansch, Corwin ;

Verma, Rajeshwar R. .

CHEMMEDCHEM, 2007, 2 (12) :1807-1813

[27]

Hansch C, 2007, TOP HETEROCYCL CHEM, V10, P43, DOI 10.1007/7081_2007_060

[28] Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin [J].

Hautefaye, P ;

Cimetière, B ;

Pierré, A ;

Léonce, S ;

Hickman, J ;

Laine, W ;

Bailly, C ;

Lavielle, G .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (16) :2731-2735

[29] Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins [J].

He, XG ;

Lu, W ;

Jiang, XQ ;

Cai, JC ;

Zhang, XW ;

Ding, J .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (15) :4003-4008

[30] Recq15 Plays an Important Role in DNA Replication and Cell Survival after Camptothecin Treatment [J].

Hu, Yiduo ;

Lu, Xincheng ;

Zhou, Guangjin ;

Barnes, Ellen L. ;

Luo, Guangbin .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (01) :114-123

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