A Review on Camptothecin Analogs with Promising Cytotoxic Profile

被引：20
作者：
Amin, Sk Abdul [1 ,2 ]
Adhikari, Nilanjan [1 ]
Jha, Tarun [1 ]
Gayen, Shovanlal [2 ]
机构：
[1] Jadavpur Univ, Dept Pharmaceut Technol, Div Med & Pharmaceut Chem, Nat Sci Lab, POB 17020, Kolkata 700032, W Bengal, India
[2] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Lab Drug Design & Discovery, Sagar 470003, Madhya Pradesh, India
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 13期
关键词：
Camptothecin; homocamptothecin; topoisomerase; cytotoxicity; cancer cell lines; structure-activity relationship; quantitative structure-activity relationship; IN-VITRO CYTOTOXICITY; PLANT ANTITUMOR AGENTS; DNA TOPOISOMERASE-II; C-RING ANALOGS; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; PHYSIOLOGICAL PH; CANCER CELLS; DERIVATIVES; 20(S)-CAMPTOTHECIN;
D O I：
10.2174/1871520618666180327140956
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic agent acting against a variety of cancer cell lines. Though searches have been continued for last six decades, still it is a demanding task to design potent and cytotoxic CPTs. Different CPT analogs are synthesized to enhance the cytotoxic potential as well as to increase the pharmacokinetic properties of these analogs. Some of these analogs were proven to be clinically effective in different cancer cell lines. In this article, different CPT analogs have been highlighted extensively to get a detail insight about the structure-property relationships as well as different quantitative structure-activity relationships (QSARs) modeling of these analogs are also discussed. This study may be beneficial for designing newer CPT analogs in future.
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收藏
页码：1796 / 1814
页数：19
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