Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation

被引：70

作者：

Suiko, Masahito ^{[1
]}

Kurogi, Katsuhisa ^{[1
,2
]}

Hashiguchi, Takuyu ^{[1
]}

Sakakibara, Yoichi ^{[1
]}

Liu, Ming-Cheh ^{[2
]}

机构：

[1] Miyazaki Univ, Dept Biochem & Appl Biosci, Fac Agr, Miyazaki, Japan

[2] Univ Toledo, Dept Pharmacol, Coll Pharm & Pharmaceut Sci, 2801 W Bancroft St, Toledo, OH 43606 USA

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 01期

基金：

日本学术振兴会; 美国国家卫生研究院;

关键词：

sulfotransferase; 3-phosphoadenosine-5-phosphosulfate; Phase II; detoxifying enzymes; CATECHOL-O-METHYLTRANSFERASE; MOLECULAR-CLONING; THYROID-HORMONE; FUNCTIONAL-CHARACTERIZATION; HUMAN FETAL; ESTROGEN SULFOTRANSFERASE; CDNA CLONING; HYDROXYSTEROID SULFOTRANSFERASES; TISSUE DISTRIBUTION; OXIDATIVE STRESS;

D O I：

10.1080/09168451.2016.1222266

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytosolic sulfotransferases (SULTs) are Phase II detoxifying enzymes that mediate the sulfate conjugation of numerous xenobiotic molecules. While the research on the SULTs has lagged behind the research on Phase I cytochrome P-450 enzymes and other Phase II conjugating enzymes, it has gained more momentum in recent years. This review aims to summarize information obtained in several fronts of the research on the SULTs, including the range of the SULTs in different life forms, concerted actions of the SULTs and other Phase II enzymes, insights into the structure-function relationships of the SULTs, regulation of SULT expression and activity, developmental expression of SULTs, as well as the use of a zebrafish model for studying the developmental pharmacology/toxicology.

引用

页码：63 / 72

页数：10

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