Adenosquamous Carcinoma of Extrahepatic Bile Duct: Clinicopathologic Study of 12 Cases
被引:1
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作者:
Hong, Seung-Mo
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机构:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USAJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Hong, Seung-Mo
[1
]
Kim, Mi-Jung
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South KoreaJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Kim, Mi-Jung
[2
]
Jang, Kee-Taek
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机构:
Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South KoreaJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Jang, Kee-Taek
[3
]
Yoon, Ghil-Suk
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机构:
Kyungpook Natl Univ Hosp, Taegu, South KoreaJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Yoon, Ghil-Suk
[4
]
Cho, HyungJun
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机构:
Korea Univ, Dept Stat & Biostat, Seoul, South KoreaJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Cho, HyungJun
[5
]
Frierson, Henry F., Jr.
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机构:
Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USAJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Frierson, Henry F., Jr.
[6
]
Yu, Eunsil
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South KoreaJohns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
Yu, Eunsil
[2
]
机构:
[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea
[4] Kyungpook Natl Univ Hosp, Taegu, South Korea
[5] Korea Univ, Dept Stat & Biostat, Seoul, South Korea
[6] Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USA
来源:
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
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2008年
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1卷
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02期
关键词:
Adenosquamous carcinoma;
extrahepatic bile duct;
cholangiocarcinoma;
S100A2;
prognosis;
D O I:
暂无
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Adenosquamous carcinoma is a rare histologic subtype of extrahepatic bile duct (EBD) carcinoma and limited information is available on its clinicopathologic characteristics. Twelve cases of adenosquamous carcinoma were collected from 3 institutions and their clinicopathologic characteristics were examined and compared with those of 176 EBD adenocarcinomas. The adenocarcinoma component was more often seen at the surface of the tumor (7 of 12 cases, 58%), while the squamous carcinoma component was slightly more frequent at the advanced edge (7 of 12 cases, 58%). Immunohistochemistry, available in 10 cases, revealed that S100A2 was positive in the squamous carcinoma component in all 10 cases (100%), while it was present in the adenocarcinoma component in only 2 of 10 cases (20%, chi-square test, p= 0.001). S100A4 expression did not show any difference between the two components. Patients with adenosquamous carcinomas had worse survival (median survival, 11 months) than those with adenocarcinoma (median survival, 32 months; log-rank test, p= 0.003). Patients with predominant squamous cell carcinoma component at the leading edge had worse survival than those without it. In conclusion, patients with adenosquamous carcinoma demonstrated worse survival than those with pure adenocarcinoma. S100A2 immunohistochemical staining may be helpful in detecting the squamous component.
机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Yokohama Rosai Hosp, Div Pathol, Yokohama, Kanagawa, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Kubota, Kensuke
Kakuta, Yukio
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机构:
Yokohama Rosai Hosp, Div Pathol, Yokohama, Kanagawa, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Kakuta, Yukio
Inayama, Yoshiaki
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机构:
Yokohama City Univ, Div Pathol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Inayama, Yoshiaki
Yoneda, Masato
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Yoneda, Masato
Abe, Yasunobu
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Abe, Yasunobu
Inamori, Masahiko
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Inamori, Masahiko
Kirikoshi, Hiroyuki
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Kirikoshi, Hiroyuki
Saito, Satoru
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Saito, Satoru
Nakajima, Atsushi
论文数: 0引用数: 0
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机构:
Yokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Nakajima, Atsushi
Sugimori, Kazuya
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Urafune Hosp, Div Gastroenterol, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Sugimori, Kazuya
Matuo, Kenichi
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Med, Div Surg, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Matuo, Kenichi
Kazunaga, Takeda
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Grad Sch Med, Div Surg, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
Kazunaga, Takeda
Shimada, Hiroshi
论文数: 0引用数: 0
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机构:
Yokohama City Univ, Grad Sch Med, Div Surg, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Div Gastroenterol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan
机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
Lee, SJ
Park, SW
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机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
Park, SW
Song, SY
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机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
Song, SY
Chung, JB
论文数: 0引用数: 0
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机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
Chung, JB
Moon, YM
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机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
Moon, YM
Kang, JK
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机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
Kang, JK
Park, IS
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South KoreaYonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea
机构:
CIUDAD SANIT FRANCISCO FRANCO,DEPT CIRUGIA,SERV CIRUGIA GEN,BARCELONA,SPAINCIUDAD SANIT FRANCISCO FRANCO,DEPT CIRUGIA,SERV CIRUGIA GEN,BARCELONA,SPAIN