Adenosquamous Carcinoma of Extrahepatic Bile Duct: Clinicopathologic Study of 12 Cases

被引:1
|
作者
Hong, Seung-Mo [1 ]
Kim, Mi-Jung [2 ]
Jang, Kee-Taek [3 ]
Yoon, Ghil-Suk [4 ]
Cho, HyungJun [5 ]
Frierson, Henry F., Jr. [6 ]
Yu, Eunsil [2 ]
机构
[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21209 USA
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea
[4] Kyungpook Natl Univ Hosp, Taegu, South Korea
[5] Korea Univ, Dept Stat & Biostat, Seoul, South Korea
[6] Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USA
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2008年 / 1卷 / 02期
关键词
Adenosquamous carcinoma; extrahepatic bile duct; cholangiocarcinoma; S100A2; prognosis;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Adenosquamous carcinoma is a rare histologic subtype of extrahepatic bile duct (EBD) carcinoma and limited information is available on its clinicopathologic characteristics. Twelve cases of adenosquamous carcinoma were collected from 3 institutions and their clinicopathologic characteristics were examined and compared with those of 176 EBD adenocarcinomas. The adenocarcinoma component was more often seen at the surface of the tumor (7 of 12 cases, 58%), while the squamous carcinoma component was slightly more frequent at the advanced edge (7 of 12 cases, 58%). Immunohistochemistry, available in 10 cases, revealed that S100A2 was positive in the squamous carcinoma component in all 10 cases (100%), while it was present in the adenocarcinoma component in only 2 of 10 cases (20%, chi-square test, p= 0.001). S100A4 expression did not show any difference between the two components. Patients with adenosquamous carcinomas had worse survival (median survival, 11 months) than those with adenocarcinoma (median survival, 32 months; log-rank test, p= 0.003). Patients with predominant squamous cell carcinoma component at the leading edge had worse survival than those without it. In conclusion, patients with adenosquamous carcinoma demonstrated worse survival than those with pure adenocarcinoma. S100A2 immunohistochemical staining may be helpful in detecting the squamous component.
引用
收藏
页码:147 / 156
页数:10
相关论文
共 50 条
  • [41] Impact of the histological phenotype of extrahepatic bile duct carcinoma
    Okano, Kensuke
    Yoshizawa, Tadashi
    Miura, Takuya
    Ishido, Keinosuke
    Kudo, Daisuke
    Kimura, Norihisa
    Wakiya, Tai-Ichi
    Wu, Yunyan
    Morohashi, Satoko
    Hakamada, Kenichi
    Kijima, Hiroshi
    MOLECULAR AND CLINICAL ONCOLOGY, 2018, 8 (01) : 54 - 60
  • [42] Neuroendocrine carcinoma of the extrahepatic bile duct: A case report
    Oshiro, Yukio
    Gen, Ryozo
    Hashimoto, Shinji
    Oda, Tatsuya
    Sato, Taiki
    Ohkohchi, Nobuhiro
    WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (30) : 6960 - 6964
  • [43] Invasive papillary carcinomas of the extrahepatic bile ducts: a clinicopathologic and immunohistochemical study of 13 cases
    Hoang, MP
    Murakata, LA
    Katabi, N
    Henson, DE
    Albores-Saavedra, J
    MODERN PATHOLOGY, 2002, 15 (12) : 1251 - 1258
  • [44] Clinicopathologic study of resected cases of primary carcinoma of the cystic duct
    Kubota, Kensuke
    Kakuta, Yukio
    Inayama, Yoshiaki
    Yoneda, Masato
    Abe, Yasunobu
    Inamori, Masahiko
    Kirikoshi, Hiroyuki
    Saito, Satoru
    Nakajima, Atsushi
    Sugimori, Kazuya
    Matuo, Kenichi
    Kazunaga, Takeda
    Shimada, Hiroshi
    HEPATO-GASTROENTEROLOGY, 2008, 55 (85) : 1174 - 1178
  • [45] INFILTRATING SALIVARY DUCT CARCINOMA - A CLINICOPATHOLOGIC STUDY OF 5 CASES
    CHEN, KTK
    HAFEZ, GR
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1981, 107 (01) : 37 - 39
  • [46] A clinicopathologic study of primary adenosquamous carcinoma of the liver
    Kobayashi, M
    Okabayashi, T
    Okamoto, K
    Namikawa, T
    Araki, K
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2005, 39 (06) : 544 - 548
  • [47] A phase I/II study of radiochemotherapy in extrahepatic bile duct carcinoma.
    Schoppmeyer, K
    Miethe, S
    Witzigmann, H
    Hauss, J
    Moessner, J
    Hildebrandt, G
    Caca, K
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 365S - 365S
  • [48] Cholangiographic characteristics in cases with hepatocellular carcinoma induced intraductal extrahepatic bile duct obstruction.
    Lee, SJ
    Park, SW
    Song, SY
    Chung, JB
    Moon, YM
    Kang, JK
    Park, IS
    GASTROENTEROLOGY, 1998, 114 (04) : A529 - A529
  • [49] 5 CASES INVOLVING EXTRAHEPATIC BILE-DUCT ANOMALIES
    PAGES, A
    MARTYDOU.C
    BARNEON, G
    ARCHIVES FRANCAISES DE PEDIATRIE, 1973, 30 (08): : 883 - 884
  • [50] EXTRAHEPATIC BILE-DUCT NEOPLASIAS - WITH REFERENCE TO 26 CASES
    OLSINAPAVIA, J
    CIRUGIA ESPANOLA, 1976, 30 (04): : 369 - 388