Synthesis and protein kinase C binding activity of benzolactam-V7

被引：29

作者：

Ma, DW

Wang, GQ

Wang, SM

Kozikowski, AP

Lewin, NE

Blumberg, PM

机构：

[1] Georgetown Univ, Med Ctr, Inst Cognit & Computat Sci, Drug Discovery Lab, Washington, DC 20007 USA

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[3] NCI, Bethesda, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 10期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(99)00207-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKC alpha. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1371 / 1374

页数：4

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