RNA Polymerase II Transcription Elongation Control

被引：95
作者：
Guo, Jiannan [1 ]
Price, David H. [1 ]
机构：
[1] Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA
来源：
CHEMICAL REVIEWS | 2013年 / 113卷 / 11期
基金：
美国国家卫生研究院;
关键词：
PRE-MESSENGER-RNA; C-TERMINAL DOMAIN; QUALITY-CONTROL MECHANISM; BROMODOMAIN PROTEIN BRD4; CLEAVAGE FACTOR TFIIS; EMBRYONIC STEM-CELLS; HEAT-SHOCK GENES; FACTOR P-TEFB; POL-II; 7SK SNRNA;
D O I：
10.1021/cr400105n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Regulation of gene expression is critical in determining cell identity, development, and responses to the cellular environment. DNA is the inherited source of genetic information, and regulation of gene expression starts with selection of which genes will undergo transcription. RNA, the product of transcription, is then utilized to generate functional products, including being translated into protein or processed into functional RNA. GTFs are required for Pol II initiation on every promoter, regardless of the strength of the promoter. The regulation by activators and repressors is conveyed through a conserved multisubunit complex termed the Mediator. The human Mediator contains about 30 subunits and is 1.2 MDa in size, making the PIC approximately 3.5 MDa. Known to interact with Pol II and several GTFs, the Mediator is viewed as a platform that responds to different activators for regulating ranscription in different ways.
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收藏
页码：8583 / 8603
页数：21
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