Palladium-Catalyzed Oxidative Annulation of Acrylic Acid and Amide with Alkynes: A Practical Route to Synthesize α-Pyrones and Pyridones

被引：63
|
作者：
Yu, Yue [1 ]
Huang, Liangbin [1 ]
Wu, Wanqing [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 08期
基金：
中国国家自然科学基金;
关键词：
AEROBIC INTERMOLECULAR CYCLIZATION; OXO GOLD CARBENES; C-H ACTIVATION; BENZOIC-ACIDS; GAMMA; DERIVATIVES; ALKENES; BONDS; BETA; ACETOXYPALLADATION;
D O I：
10.1021/ol500611d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A range of internal alkynes smoothly underwent palladium-catalyzed oxidative annulations with acrylic acid and amide to afford alpha-pyrones and pyridones in good to excellent yields with high regioselectivity. The usage of O-2 (1 atm) as a stoichiometric oxidant with H2O as the only byproduct under mild conditions makes this process more attractive and practical.
引用
收藏
页码：2146 / 2149
页数：4
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