A Signature of Attention-Elicited Electrocortical Activity Distinguishes Response From Non-Response to the Non-Stimulant Atomoxetine in Children and Adolescents With ADHD

被引：3

作者：

Griffiths, Kristi R. ^{[1
]}

Jurigova, Barbora G. ^{[1
]}

Leikauf, John E. ^{[2
]}

Palmer, Donna ^{[3
]}

Clarke, Simon D. ^{[1
,4
,6
]}

Tsang, Tracey W. ^{[1
,7
]}

Teber, Erdahl T. ^{[8
]}

Kohn, Michael R. ^{[1
,5
,6
]}

Williams, Leanne M. ^{[2
]}

机构：

[1] Univ Sydney, Westmead Inst Med Res, Brain Dynam Ctr, Westmead, NSW, Australia

[2] Stanford Univ, Psychiat & Behav Sci, 401 Quarry Rd,Mail Code 5717, Palo Alto, CA 94305 USA

[3] Brain Resource, Sydney, NSW, Australia

[4] Westmead Hosp, Adolescent & Young Adult Med, Paediat, Westmead, NSW, Australia

[5] Westmead Hosp, Adolescent & Young Adult Med, Westmead, NSW, Australia

[6] Ctr Res Adolescents Hlth, Westmead, NSW, Australia

[7] Univ Sydney, Sydney Med Sch, Discipline Child & Adolescent Hlth, Sydney, NSW, Australia

[8] Childrens Med Res Inst, Westmead, NSW, Australia

来源：

JOURNAL OF ATTENTION DISORDERS | 2019年 / 23卷 / 07期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

ADHD; atomoxetine; event-related potentials; N200; P300; DEFICIT HYPERACTIVITY DISORDER; EVENT-RELATED POTENTIALS; TEST-RETEST RELIABILITY; DEFICIT/HYPERACTIVITY DISORDER; INTEGRATIVE THEORY; OPEN-LABEL; P300; EFFICACY; PLACEBO; NOREPINEPHRINE;

D O I：

10.1177/1087054717733044

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: Atomoxetine has several characteristics that make it an attractive alternative to stimulants for treating ADHD, but there are currently no tests identifying individuals for whom the medication should be a first-line option. Method: Within the ADHD Controlled Trial Investigation Of a Non-stimulant (ACTION) study, we examined neuro-cortical activity in 52 youth with ADHD. Baseline event-related potentials (ERP) were compared between those who subsequently responded to 6 weeks of atomoxetine versus those who did not. Results: Responders were distinguished by significantly lower auditory oddball N2 amplitudes than both non-responders and typically developing controls, particularly in the right frontocentral region (p = .002, Cohen's d = 1.1). Leave-one-out cross validation determined that N2 amplitude in this region was able to accurately predict non-responders with a specificity of 80.8%. There were no P3 differences between responders and non-responders. Conclusion: The N2 amplitude is a biomarker that may have utility in predicting response to atomoxetine for youth with ADHD.

引用

页码：744 / 753

页数：10

共 3 条

[1] Cardiovascular Effects of Stimulant and Non-Stimulant Medication for Children and Adolescents with ADHD: A Systematic Review and Meta-Analysis of Trials of Methylphenidate, Amphetamines and Atomoxetine
Leonie Hennissen
Mireille J. Bakker
Tobias Banaschewski
Sara Carucci
David Coghill
Marina Danckaerts
Ralf W. Dittmann
Chris Hollis
Hanna Kovshoff
Suzanne McCarthy
Peter Nagy
Edmund Sonuga-Barke
Ian C. K. Wong
Alessandro Zuddas
Eric Rosenthal
Jan K. Buitelaar
CNS Drugs, 2017, 31 : 199 - 215
[2] Functional outcomes from a head-to-head, randomized, double-blind trial of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder and an inadequate response to methylphenidate
Nagy, Peter
Haege, Alexander
Coghill, David R.
Caballero, Beatriz
Adeyi, Ben
Anderson, Colleen S.
Sikirica, Vanja
Cardo, Esther
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2016, 25 (02) : 141 - 149
[3] Functional outcomes from a head-to-head, randomized, double-blind trial of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder and an inadequate response to methylphenidate
Peter Nagy
Alexander Häge
David R. Coghill
Beatriz Caballero
Ben Adeyi
Colleen S. Anderson
Vanja Sikirica
Esther Cardo
European Child & Adolescent Psychiatry, 2016, 25 : 141 - 149

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