In vitro effects of vitamin C and selenium on NK activity of patients with β-thalassemia major

被引：22
作者：
Atasever, B
Ertan, NZ [1 ]
Erdem-Kuruca, S
Karakas, Z
机构：
[1] Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34390 Istanbul, Turkey
[2] Istanbul Univ, Istanbul Fac Med, Dept Pediat, TR-34390 Istanbul, Turkey
来源：
PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2006年 / 23卷 / 03期
关键词：
antioxidant; NK activity; oxidative stress; selenium; beta-thalassemia; vitamin C;
D O I：
10.1080/08880010500506420
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this study, the in vitro effects of vitamin C and selenium on natural killer (NK) cell activity of beta-thalassemia major patients was investigated. At first, significant decreased NK activity was found at E:T ratios of 1:1, 5:1, and 10:1 in whole thalassemia patients. Low-dose selenium treatment enhanced NK activity in patients but there was no change in the control group. High-dose selenium decreased NK activity significantly in splenectomized patients. Different doses vitamin C enhanced NK activity significantly in both splenectomized and unsplenectomized patients. According to these results, selenium dosage should be arranged carefully in thalassemia patients, whereas vitamin C can be used confidently.
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收藏
页码：187 / 197
页数：11
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