The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

被引：303
作者：
Canani, Roberto Berni [1 ,2 ]
Di Costanzo, Margherita [1 ]
Leone, Ludovica [1 ]
机构：
[1] Univ Naples Federico II, Dept Pediat, I-80131 Naples, Italy
[2] Univ Naples Federico II, European Lab Invest Food Induced Dis, I-80131 Naples, Italy
来源：
CLINICAL EPIGENETICS | 2012年 / 4卷
关键词：
epigenome; histone deacetylase inhibitor; short chain fatty acids; HISTONE-DEACETYLASE INHIBITORS; FUTURE PHARMACOLOGICAL-TREATMENT; CHAIN FATTY-ACIDS; SODIUM-BUTYRATE; GENE-EXPRESSION; MOLECULAR-MECHANISMS; CATHELICIDIN LL-37; ULCERATIVE-COLITIS; DIETARY FIBER; CELL-LINE;
D O I：
10.1186/1868-7083-4-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in the colon. In the last decade, multiple beneficial effects of butyrate at intestinal and extraintestinal level have been demonstrated. The mechanisms of action of butyrate are different and many of these involve an epigenetic regulation of gene expression through the inhibition of histone deacetylase. There is a growing interest in butyrate because its impact on epigenetic mechanisms will lead to more specific and efficacious therapeutic strategies for the prevention and treatment of different diseases ranging from genetic/metabolic conditions to neurological degenerative disorders. This review is focused on recent data regarding the epigenetic effects of butyrate with potential clinical implications in human medicine.
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页数：7
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