Multitissue Multiomics Systems Biology to Dissect Complex Diseases

被引：50

作者：

Yang, Xia ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90032 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 08期

关键词：

OMICS; ENVIRONMENT; NETWORKS; OBESITY;

D O I：

10.1016/j.molmed.2020.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most complex diseases involve genetic and environmental risk factors, engage multiple cells and tissues, and follow a polygenic or omnigenic model depicting numerous genes contributing to pathophysiology. These multidimensional complexities pose challenges to traditional approaches that examine individual factors. In turn, multitissue multiomics systems biology has emerged to compre-hensively elucidate within-and cross-tissue molecular networks underlying gene-by-environment interactions and contributing to complex diseases. The power of systems biology in retrieving novel insights and formulating new hypotheses has been well documented. However, the field faces various challenges that call for debate and action. In this opinion article, I discuss the concepts, benefits, current state, and challenges of the field and point to the next steps toward network-based systems medicine.

引用

页码：718 / 728

页数：11

共 56 条

[21] Gene-environment interactions in human diseases [J].

Hunter, DJ .

NATURE REVIEWS GENETICS, 2005, 6 (04) :287-298

[22] Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease [J].

Krishnan, Karthickeyan Chella ;

Kurt, Zeyneb ;

Barrere-Cain, Rio ;

Sabir, Simon ;

Das, Aditi ;

Floyd, Raquel ;

Vergnes, Laurent ;

Zhao, Yuqi ;

Che, Nam ;

Charugundla, Sarada ;

Qi, Hannah ;

Zhou, Zhiqiang ;

Meng, Yonghong ;

Pan, Calvin ;

Seldin, Marcus M. ;

Norheim, Frode ;

Hui, Simon ;

Reue, Karen ;

Lusis, Aldons J. ;

Yang, Xia .

CELL SYSTEMS, 2018, 6 (01) :103-+

[23] Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease [J].

Kurt, Zeyneb ;

Barrere-Cain, Rio ;

LaGuardia, Jonnby ;

Mehrabian, Margarete ;

Pan, Calvin ;

Hui, Simon T. ;

Norheim, Frode ;

Zhou, Zhiqiang ;

Hasin, Yehudit ;

Lusis, Aldons J. ;

Yang, Xia .

BIOLOGY OF SEX DIFFERENCES, 2018, 9

[24] Network analyses identify liver-specific targets for treating liver diseases [J].

Lee, Sunjae ;

Zhang, Cheng ;

Liu, Zhengtao ;

Klevstig, Martina ;

Mukhopadhyay, Bani ;

Bergentall, Mattias ;

Cinar, Resat ;

Stahlman, Marcus ;

Sikanic, Natasha ;

Park, Joshua K. ;

Deshmukh, Sumit ;

Harzandi, Azadeh M. ;

Kuijpers, Tim ;

Grotli, Morten ;

Elsasser, Simon J. ;

Piening, Brian D. ;

Snyder, Michael ;

Smith, Ulf ;

Nielsen, Jens ;

Backhed, Fredrik ;

Kunos, George ;

Uhlen, Mathias ;

Boren, Jan ;

Mardinoglu, Adil .

MOLECULAR SYSTEMS BIOLOGY, 2017, 13 (08)

[25] Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance [J].

Lee, Sunjae ;

Zhang, Cheng ;

Kilicarslan, Murat ;

Piening, Brian D. ;

Bjornson, Elias ;

Hallstrom, Bjorn M. ;

Groen, Albert K. ;

Ferrannini, Ele ;

Laakso, Markku ;

Snyder, Michael ;

Bluher, Matthias ;

Uhlen, Mathias ;

Nielsen, Jens ;

Smith, Ulf ;

Serlie, Mireille J. ;

Boren, Jan ;

Mardinoglu, Adil .

CELL METABOLISM, 2016, 24 (01) :172-184

[26] Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets [J].

Lempiainen, Harri ;

Braenne, Ingrid ;

Michoel, Tom ;

Tragante, Vinicius ;

Vilne, Baiba ;

Webb, Tom R. ;

Kyriakou, Theodosios ;

Eichner, Johannes ;

Zeng, Lingyao ;

Willenborg, Christina ;

Franzen, Oscar ;

Ruusalepp, Arno ;

Goel, Anuj ;

van der Laan, Sander W. ;

Biegert, Claudia ;

Hamby, Stephen ;

Talukdar, Husain A. ;

Asl, Hassan Foroughi ;

Pasterkamp, Gerard ;

Watkins, Hugh ;

Samani, Nilesh J. ;

Wittenberger, Timo ;

Erdmann, Jeanette ;

Schunkert, Heribert ;

Asselbergs, Folkert W. ;

Bjorkegren, Johan L. M. .

SCIENTIFIC REPORTS, 2018, 8

[27]

Libby P, 2019, NAT REV DIS PRIMERS, V5, DOI [10.1038/s41572-019-0106-z, 10.1038/s41572-019-0116-x]

[28] More on Data Sharing Reply [J].

Longo, Dan L. ;

Drazen, Jeffrey M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (19) :1896-1897

[29] Data Sharing [J].

Longo, Dan L. ;

Drazen, Jeffrey M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (03) :276-277

[30] Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease [J].

Makinen, Ville-Petteri ;

Civelek, Mete ;

Meng, Qingying ;

Zhang, Bin ;

Zhu, Jun ;

Levian, Candace ;

Huan, Tianxiao ;

Segre, Ayellet V. ;

Ghosh, Sujoy ;

Vivar, Juan ;

Nikpay, Majid ;

Stewart, Alexandre F. R. ;

Nelson, Christopher P. ;

Willenborg, Christina ;

Erdmann, Jeanette ;

Blakenberg, Stefan ;

O'Donnell, Christopher J. ;

Marz, Winfried ;

Laaksonen, Reijo ;

Epstein, Stephen E. ;

Kathiresan, Sekar ;

Shah, Svati H. ;

Hazen, Stanley L. ;

Reilly, Muredach P. ;

Lusis, Aldons J. ;

Samani, Nilesh J. ;

Schunkert, Heribert ;

Quertermous, Thomas ;

McPherson, Ruth ;

Yang, Xia ;

Assimes, Themistocles L. .

PLOS GENETICS, 2014, 10 (07)

← 1 2 3 4 5 6 →