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STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria
被引:25
作者:

Chen, Ting-Ting
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Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan

Tsai, Ming-Hsun
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Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan

Kung, John T.
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Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan

Lin, Kuo-I
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Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan

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Lee, Chien-Kuo
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Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan
机构:
[1] Natl Taiwan Univ, Grad Inst Immunol, Coll Med, Taipei 100, Taiwan
[2] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan
[3] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[4] Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria
关键词:
TOLL-LIKE RECEPTORS;
T-BET;
CHROMATIN IMMUNOPRECIPITATION;
LYMPHOCYTE DIFFERENTIATION;
STREPTOCOCCUS-PNEUMONIAE;
AUTOANTIBODY PRODUCTION;
TRANSCRIPTION FACTOR;
IMMUNE-RESPONSE;
DOWN-REGULATION;
INNATE;
D O I:
10.1084/jem.20151620
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Marginal zone B (MZ B) cells can rapidly produce antibody in response to infection with blood-borne encapsulated pathogens. Although TLR-mediated activation of MZ B is known to trigger humoral immune response, the signal cascade directing this response remains undefined. Here, we demonstrate that STAT1 plays an essential role in TLR-mediated antibody response of MZ B cells. Further, the TLR-induced IgM response is impaired in a type I and type II IFN-independent manner. Although activation, proliferation, and apoptosis are not affected, both differentiation into plasma cells and IgM production are impaired in Stat1(-/-) MZ B cells. Interestingly, STAT1 directly regulates the expression of Prdm1 (encodes BLIMP-1) by binding to its promoter, and Prdm1 expression is reduced in Stat1(-/-) MZ B cells. Restoration of BLIMP-1 to cells rescues TLR-induced IgM response. Moreover, Stat1(-/-) mice are more susceptible to S. pneumoniae infection, which can be rescued by the serum of bacteria-primed WT mice. The increased susceptibility to S. pneumoniae infection in Stat1(-/-) mice is also intrinsic to STAT1 requirement in MZ B cells. Collectively, these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation.
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页码:3025 / 3039
页数:15
相关论文
共 66 条
[1]
Toll-like receptors: critical proteins linking innate and acquired immunity
[J].
Akira, S
;
Takeda, K
;
Kaisho, T
.
NATURE IMMUNOLOGY,
2001, 2 (08)
:675-680

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka 5650871, Japan Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka 5650871, Japan

Takeda, K
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka 5650871, Japan

Kaisho, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Osaka 5650871, Japan
[2]
Blood dendritic cells interact with splenic marginal zone B cells to initiate T-Independent immune responses
[J].
Balázs, M
;
Martin, F
;
Zhou, T
;
Kearney, JF
.
IMMUNITY,
2002, 17 (03)
:341-352

Balázs, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA

Martin, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA

Zhou, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA

Kearney, JF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA Univ Alabama, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
[3]
CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response
[J].
Bancerek, Joanna
;
Poss, Zachary C.
;
Steinparzer, Iris
;
Sedlyarov, Vitaly
;
Pfaffenwimmer, Thaddaeus
;
Mikulic, Ivana
;
Doelken, Lars
;
Strobl, Birgit
;
Mueller, Mathias
;
Taatjes, Dylan J.
;
Kovarik, Pavel
.
IMMUNITY,
2013, 38 (02)
:250-262

Bancerek, Joanna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Poss, Zachary C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80303 USA Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Steinparzer, Iris
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

论文数: 引用数:
h-index:
机构:

Pfaffenwimmer, Thaddaeus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Mikulic, Ivana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Doelken, Lars
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Med, Cambridge CB2 0QQ, England Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Strobl, Birgit
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vet Med Vienna, Inst Genet & Anim Breeding, A-1210 Vienna, Austria Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Mueller, Mathias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vet Med Vienna, Inst Genet & Anim Breeding, A-1210 Vienna, Austria Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

Taatjes, Dylan J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80303 USA Univ Vienna, Max F Perutz Labs, A-1030 Vienna, Austria

论文数: 引用数:
h-index:
机构:
[4]
Autoreactivity by design: Innate B and T lymphocytes
[J].
Bendelac, A
;
Bonneville, M
;
Kearney, JF
.
NATURE REVIEWS IMMUNOLOGY,
2001, 1 (03)
:177-186

Bendelac, A
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

Bonneville, M
论文数: 0 引用数: 0
h-index: 0
机构: Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

Kearney, JF
论文数: 0 引用数: 0
h-index: 0
机构: Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
[5]
The Toll-like receptors: analysis by forward genetic methods
[J].
Beutler, B
.
IMMUNOGENETICS,
2005, 57 (06)
:385-392

Beutler, B
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, La Jolla, CA 92037 USA Scripps Res Inst, La Jolla, CA 92037 USA
[6]
Crosstalk between STATs and TLRs TRAF6 is a nexus for TLR-STAT1 crosstalk
[J].
Bezbradica, Jelena S.
;
Schroder, Kate
.
IMMUNOLOGY AND CELL BIOLOGY,
2014, 92 (09)
:737-738

Bezbradica, Jelena S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia

Schroder, Kate
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia
[7]
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes
[J].
Boisson-Dupuis, Stephanie
;
Kong, Xiao-Fei
;
Okada, Satoshi
;
Cypowyj, Sophie
;
Puel, Anne
;
Abel, Laurent
;
Casanova, Jean-Laurent
.
CURRENT OPINION IN IMMUNOLOGY,
2012, 24 (04)
:364-378

Boisson-Dupuis, Stephanie
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA
INSERM, Lab Human Genet Infect Dis, Necker Branch, Necker Med Sch,U980, Paris, France
Paris Descartes Univ, Necker Med Sch, Paris, France Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA

Kong, Xiao-Fei
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA

Okada, Satoshi
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA

Cypowyj, Sophie
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA

Puel, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, Lab Human Genet Infect Dis, Necker Branch, Necker Med Sch,U980, Paris, France
Paris Descartes Univ, Necker Med Sch, Paris, France Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA

论文数: 引用数:
h-index:
机构:

Casanova, Jean-Laurent
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA
INSERM, Lab Human Genet Infect Dis, Necker Branch, Necker Med Sch,U980, Paris, France
Paris Descartes Univ, Necker Med Sch, Paris, France
Hop Necker Enfants Malad, Pediat Hematol Immunol Unit, Dept Pediat, Paris, France Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, New York, NY 10021 USA
[8]
ANTI-PHOSPHOCHOLINE ANTIBODIES FOUND IN NORMAL MOUSE SERUM ARE PROTECTIVE AGAINST INTRAVENOUS INFECTION WITH TYPE-3 STREPTOCOCCUS-PNEUMONIAE
[J].
BRILES, DE
;
NAHM, M
;
SCHROER, K
;
DAVIE, J
;
BAKER, P
;
KEARNEY, J
;
BARLETTA, R
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1981, 153 (03)
:694-705

BRILES, DE
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

NAHM, M
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

SCHROER, K
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

DAVIE, J
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

BAKER, P
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

KEARNEY, J
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110

BARLETTA, R
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ST LOUIS,MO 63110
[9]
MOUSE IGG3 ANTIBODIES ARE HIGHLY PROTECTIVE AGAINST INFECTION WITH STREPTOCOCCUS-PNEUMONIAE
[J].
BRILES, DE
;
CLAFLIN, JL
;
SCHROER, K
;
FORMAN, C
.
NATURE,
1981, 294 (5836)
:88-90

BRILES, DE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA, CTR COMPREHENS CANC, BIRMINGHAM, AL 35294 USA

CLAFLIN, JL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA, CTR COMPREHENS CANC, BIRMINGHAM, AL 35294 USA

SCHROER, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA, CTR COMPREHENS CANC, BIRMINGHAM, AL 35294 USA

FORMAN, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA, CTR COMPREHENS CANC, BIRMINGHAM, AL 35294 USA
[10]
The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
[J].
Carotta, Sebastian
;
Willis, Simon N.
;
Hasbold, Jhagvaral
;
Inouye, Michael
;
Pang, Swee Heng Milon
;
Emslie, Dianne
;
Light, Amanda
;
Chopin, Michael
;
Shi, Wei
;
Wang, Hongsheng
;
Morse, Herbert C., III
;
Tarlinton, David M.
;
Corcoran, Lynn M.
;
Hodgkin, Philip D.
;
Nutt, Stephen L.
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2014, 211 (11)
:2169-2181

Carotta, Sebastian
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Willis, Simon N.
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Hasbold, Jhagvaral
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Inouye, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia
Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Pang, Swee Heng Milon
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Emslie, Dianne
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Light, Amanda
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

论文数: 引用数:
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Shi, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Comp & Informat Syst, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Wang, Hongsheng
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Morse, Herbert C., III
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Tarlinton, David M.
论文数: 0 引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Corcoran, Lynn M.
论文数: 0 引用数: 0
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Hodgkin, Philip D.
论文数: 0 引用数: 0
h-index: 0
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Nutt, Stephen L.
论文数: 0 引用数: 0
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia