Ultrasensitive DNA detection using photonic crystals

被引：152

作者：

Li, Mingzhu ^{[1
]}

He, Fang ^{[1
]}

Liao, Qing ^{[1
]}

Liu, Jian ^{[1
]}

Xu, Liang ^{[1
]}

Jiang, Lei ^{[1
]}

Song, Yanlin ^{[1
]}

Wang, Shu ^{[1
]}

Zhu, Daoben ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, New Mat Lab,Inst Chem, Beijing 100190, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 38期

关键词：

base-pair mismatch; DNA; FRET; hybridization; photonic crystals;

D O I：

10.1002/anie.200801998

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A strong signal: A fluorescence resonance energy transfer (FRET)-based DNA hybridization detection method uses a photonic crystal to amplify the optical signal (see picture). Single-mismatch selectivity and a sensitivity of about 13.5 fM are achieved. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7258 / 7262

页数：5

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