Indicators for lack of systemic availability of organic pigments

被引:8
|
作者
Stratmann, Heidi [1 ]
Hellmund, Maria [2 ]
Veith, Ulrich [3 ]
End, Nicole [3 ]
Teubner, Wera [2 ]
机构
[1] BASF Schweiz AG, Dept Prod Safety, Basel, Switzerland
[2] BASF Serv Europe GmbH, Dept Prod Safety Serv, Berlin, Germany
[3] BASF Colors & Effects Switzerland AG, Dept Prod Stewardship, Basel, Switzerland
关键词
Organic pigments; Solubility; Non-polar; Planar; Bioavailability; Low toxicity; REACH; ECHA; CRYSTAL;
D O I
10.1016/j.yrtph.2020.104719
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Experimental data of all 143 organic pigments registered with the European Chemicals Agency, of which 88 were listed in a nanomaterial inventory, was retrieved from the registered substance fact sheets. Availability of the data was 93% for solubility, 82% for bacterial mutagenicity, 79% for acute oral toxicity, 75% for irritation, 59% for skin sensitisation, 36% for repeated dose toxicity and 34% for each clastogenicity and mutagenicity in mammalian cells and 23% for toxicity to reproduction. Pigments mostly had a water and octanol solubility of significantly below 0.1 mg/L, but fourteen were found to be of higher solubility. None were irritating to skin and eyes. Except for the metal salt and the (3-naphthol pigments, none of the insoluble pigments showed adverse effects up to limit doses indicating that poor solubility prevents systemic uptake of toxicologically relevant amounts. The few available toxicokinetic data shows absence of metabolism or significant uptake and is in support of this. Occasional effects observed on bacterial mutagenicity and skin sensitisation are attributed to impurities. There is no indication that for organic pigments other particle characteristics such as surface area or morphology have an impact on the investigated toxicological endpoints.
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页数:9
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