Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls

被引：23

作者：

Malhi, Gin S. ^{[1
,2
,3
,4
]}

Das, Pritha ^{[1
,2
,3
,4
]}

Outhred, Tim ^{[1
,2
,3
,4
]}

Dobson-Stone, Carol ^{[5
,6
]}

Irwin, Lauren ^{[1
,2
,3
]}

Gessler, Danielle ^{[1
,2
,3
,4
,5
,7
]}

Bryant, Richard ^{[8
]}

Mannie, Zola ^{[1
,2
,3
,4
,9
,10
]}

机构：

[1] Northern Sydney Local Hlth Dist, Acad Dept Psychiat, Sydney, NSW, Australia

[2] Univ Sydney, Sydney Med Sch Northern, ARCHI, Dept Psychiat, Sydney, NSW, Australia

[3] Univ Sydney, Fac Med & Hlth, Northern Clin Sch, Dept Psychiat, Sydney, NSW 2065, Australia

[4] Royal North Shore Hosp, CADE Clin, Dept Acad Psychiat, Northern Sydney Local Hlth Dist, Sydney, NSW, Australia

[5] Univ Sydney, Fac Med & Hlth, Brain & Mind Ctr, Sydney, NSW, Australia

[6] Univ New South Wales, Sch Med Sci, Fac Sci, Sydney, NSW, Australia

[7] Univ Sydney, Sch Psychol, Dept Mus & Performing Arts Profess, Sydney, NSW, Australia

[8] Univ New South Wales, Sch Psychol, Fac Sci, Sydney, NSW, Australia

[9] NSW Hlth, Sydney, NSW, Australia

[10] Royal North Shore Hosp, Northern Sydney Local Hlth Dist, Sydney, NSW, Australia

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | 2019年 / 53卷 / 04期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Stress genes; childhood trauma; adolescence; hippocampus; cortisol; mood disorders; vulnerability; resilience; GLUCOCORTICOID-RECEPTOR POLYMORPHISMS; CHILDHOOD TRAUMA; EMOTION REGULATION; LIFE STRESS; DEPRESSION; RESILIENCE; BRAIN; ABUSE; VULNERABILITY; MALTREATMENT;

D O I：

10.1177/0004867419827649

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Adolescence is a time of increased susceptibility to environmental stress and mood disorders, and girls are particularly at risk. Genes interacting with the environment (G x E) are implicated in hypothalamic-pituitary-adrenal axis dysregulation, hippocampal volume changes and risk or resilience to mood disorders. In this study, we assessed the effects of stress system G x E interactions on hippocampal volumes and cortisol secretion in adolescent girls. Methods: We recruited 229 girls aged 12-18 years, and scans were obtained from 202 girls. Of these, 76 had been exposed to higher emotional trauma (abuse or neglect). Hippocampal volumes were measured using Freesurfer and high-resolution structural magnetic resonance imaging scans. Saliva samples were collected for measurement of cortisol levels and genotyping of stress system genes: FKBP5, NR3C1 (both N = 194) and NR3C2 (N = 193). Results: Among girls with the 'G' allelic variant of the NR3C1 gene, those who had been exposed to higher emotional trauma had significantly smaller left hippocampal volumes (N = 44; mean = 4069.58 mm(3), standard deviation = 376.99) than girls who had been exposed to minimal emotional trauma with the same allelic variant (N = 69; mean = 4222.34 mm(3), standard deviation = 366.74). Conclusion: In healthy adolescents, interactions between emotional trauma and the 'protective' NR3C1 'GG' variant seem to induce reductions in left hippocampal volumes. These G x E interactions suggest that vulnerability to mood disorders is perhaps driven by reduced 'protection' that may be specific to emotional trauma. This novel but preliminary evidence has implications for targeted prevention of mood disorders and prospective multimodal neuroimaging and longitudinal studies are now needed to investigate this possibility.

引用

页码：316 / 325

页数：10

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