Insulin action in thee polycystic ovary syndrome

被引：110
作者：
Dunaif, A
机构：
[1] Brigham & Womens Hosp, Div Womens Hlth, Dept Med, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Div Womens Hlth, Dept Obstet & Gynecol, Boston, MA 02115 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 02期
关键词：
D O I：
10.1016/S0889-8529(05)70073-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Polycystic ovary syndrome is associated with profound insulin resistance, conferring an approximately 7-fold increased risk for type 2 diabetes mellitus in premenopausal women. The mechanisms of insulin resistance in PCOS are distinct from those in obesity and in typical type 2 diabetes mellitus. There also is evidence for pancreatic beta-cell dysfunction in PCOS that can occur independent of obesity and glucose intolerance. Insulin resistance contributes to the reproductive abnormalities of PCOS.
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页码：341 / +
页数：20
相关论文
共 57 条
[1]  
[Anonymous], 1992, POLYCYSTIC OVARY SYN
[2]   TOWARD PHYSIOLOGICAL UNDERSTANDING OF GLUCOSE-TOLERANCE - MINIMAL-MODEL APPROACH [J].
BERGMAN, RN .
DIABETES, 1989, 38 (12) :1512-1527
[3]  
Blakesley Vicky A., 1996, Cytokine and Growth Factor Reviews, V7, P153, DOI 10.1016/1359-6101(96)00015-9
[4]   EVIDENCE FOR A DEFECT IN INSULIN METABOLISM IN HYPERANDROGENIC WOMEN WITH POLYCYSTIC OVARIAN SYNDROME [J].
BUFFINGTON, CK ;
KITABCHI, AE .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1994, 43 (11) :1367-1372
[5]   CORRELATION OF HYPERANDROGENISM WITH HYPERINSULINISM IN POLYCYSTIC OVARIAN DISEASE [J].
BURGHEN, GA ;
GIVENS, JR ;
KITABCHI, AE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 50 (01) :113-116
[6]   Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity [J].
Ciaraldi, TP ;
Morales, AJ ;
Hickman, MG ;
OdomFord, R ;
Olefsky, JM ;
Yen, SSC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (05) :1421-1425
[7]   Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome [J].
Ciaraldi, TP ;
Morales, AJ ;
Hickman, MG ;
Odom-Ford, R ;
Yen, SSC ;
Olefsky, JM .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (08) :940-946
[8]   CELLULAR MECHANISMS OF INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME [J].
CIARALDI, TP ;
ELROEIY, A ;
MADAR, Z ;
REICHART, D ;
OLEFSKY, JM ;
YEN, SSC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (02) :577-583
[9]  
DAHLGREN E, 1992, FERTIL STERIL, V57, P505
[10]  
DeFronzo RA, 1997, DIABETES REV, V5, P177
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