Etiology and functional status of liver cirrhosis by 31P MR spectroscopy

被引:39
作者
Dezortova, Monika [1 ,2 ]
Taimr, Pavel [2 ,3 ]
Skoch, Antonin [1 ,2 ]
Spicak, Julius [2 ,3 ]
Hajek, Milan [1 ,2 ]
机构
[1] Dept Diagnost & Intervent Radiol, MR Unit, Prague, Czech Republic
[2] Inst Clin & Expt Med, Prague, Czech Republic
[3] Dept Hepatogastroenterol, Prague, Czech Republic
关键词
Liver cirrhosis; P-31 MR spectroscopy; Absolute concentration; Child-Pugh score; Etiology;
D O I
10.3748/wjg.v11.i44.6926
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To assess the functional status and etiology of liver cirrhosis by quantitative P-31 magnetic resonance spectroscopy (MRS). METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a H-1/P-31 surface coil by the 2D chemical shift imaging technique. Absolute concentrations of phosphomonoesters (PME), phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured. RESULTS: MRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic, viral and cholestatic etiologies based on MR spectra. Alcoholic and viral etiology differed in PDE (alcoholic, viral, controls: 6.5 +/- 2.3, 6.5 +/- 3.1, 10.8 +/- 2.7 mmol/L, P < 0.001) and ATP (alcoholic, viral, controls: 2.9 +/- 0.8, 2.8 +/- 0.9, 3.7 +/- 1.0 mmol/L, P < 0.01) from the control group. Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2 +/- 0.4, 1.6 +/- 0.6 mmol/L, P < 0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4 +/- 2.7, 6.5 +/- 2.3, 6.5 +/- 3.1 mmol/L, P < 0.005) in PDE. CONCLUSION: P-31 MRS can significantly help in non-invasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
引用
收藏
页码:6926 / 6931
页数:6
相关论文
共 19 条
[1]   A STUDY OF PATIENTS WITH ALCOHOLIC LIVER-DISEASE BY P-31 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].
ANGUS, PW ;
DIXON, RM ;
RAJAGOPALAN, B ;
RYLEY, NG ;
SIMPSON, KJ ;
PETERS, TJ ;
JEWELL, DP ;
RADDA, GK .
CLINICAL SCIENCE, 1990, 78 (01) :33-38
[2]   PROGNOSTIC VALUE OF CHILD-TURCOTTE CRITERIA IN MEDICALLY TREATED CIRRHOSIS [J].
CHRISTENSEN, E ;
SCHLICHTING, P ;
FAUERHOLDT, L ;
GLUUD, C ;
ANDERSEN, PK ;
JUHL, E ;
POULSEN, H ;
TYGSTRUP, N .
HEPATOLOGY, 1984, 4 (03) :430-435
[3]   Hepatic 31P MRS in rat models of chronic liver disease:: assessing the extent and progression of disease [J].
Corbin, IR ;
Buist, R ;
Peeling, J ;
Zhang, M ;
Uhanova, J ;
Minuk, GY .
GUT, 2003, 52 (07) :1046-1053
[4]   In vivo hepatic magnetic resonance spectroscopy: Clinical or research tool? [J].
Jalan, R ;
TaylorRobinson, SD ;
Hodgson, HJF .
JOURNAL OF HEPATOLOGY, 1996, 25 (03) :414-424
[5]  
Kiyono K, 1998, ACTA RADIOL, V39, P309
[6]   The relationship of in vivo 31P MR spectroscopy to histology in chronic hepatitis C [J].
Lim, AKP ;
Patel, N ;
Hamilton, G ;
Hajnal, JV ;
Goldin, RD ;
Taylor-Robinson, SD .
HEPATOLOGY, 2003, 37 (04) :788-794
[7]  
Meloun M., 2004, STAT ANAL EXPT DAT
[8]  
MENON DK, 1995, HEPATOLOGY, V21, P417, DOI 10.1016/0270-9139(95)90102-7
[9]   ALCOHOLIC LIVER-DISEASE - QUANTITATIVE IMAGE-GUIDED P-31 MR SPECTROSCOPY [J].
MEYERHOFF, DJ ;
BOSKA, MD ;
THOMAS, AM ;
WEINER, MW .
RADIOLOGY, 1989, 173 (02) :393-400
[10]   HEPATIC ADENINE-NUCLEOTIDE METABOLISM MEASURED INVIVO IN RATS FED ETHANOL AND A HIGH FAT-LOW PROTEIN-DIET [J].
MIYAMOTO, K ;
FRENCH, SW .
HEPATOLOGY, 1988, 8 (01) :53-60