Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

被引：42

作者：

Hosgood, H. Dean, III ^{[1
]}

Wang, Wen-Chang ^{[2
]}

Hong, Yun-Chul ^{[3
,4
]}

Wang, Jiu-Cun ^{[5
]}

Chen, Kexin ^{[6
]}

Chang, I-Shou ^{[7
]}

Chen, Chien-Jen ^{[8
,9
]}

Lu, Daru ^{[5
]}

Yin, Zhihua ^{[10
]}

Wu, Chen ^{[11
,12
,13
,14
]}

Zheng, Wei ^{[15
]}

Qian, Biyun ^{[6
]}

Park, Jae Yong

Kim, Yeul Hong ^{[18
,19
,20
]}

Chatterjee, Nilanjan ^{[1
]}

Chen, Ying ^{[21
]}

Chang, Gee-Chen ^{[22
,23
,24
,25
]}

Hsiao, Chin-Fu ^{[2
]}

Yeager, Meredith ^{[1
,26
]}

Tsai, Ying-Huang ^{[27
,28
]}

Wei, Hu ^{[1
]}

Kim, Young Tae ^{[29
,30
]}

Wu, Wei ^{[10
]}

Zhao, Zhenhong ^{[5
]}

Chow, Wong-Ho ^{[1
]}

Zhu, Xiaoling ^{[6
]}

Lo, Yen-Li ^{[2
]}

Sung, Sook Whan ^{[31
,32
]}

Chen, Kuan-Yu ^{[33
,34
]}

Yuenger, Jeff ^{[1
,26
]}

Kim, Joo Hyun

Huang, Liming ^{[11
,12
,13
,14
]}

Chen, Ying-Hsiang ^{[2
]}

Gao, Yu-Tang ^{[35
]}

Kim, Jin Hee

Huang, Ming-Shyan ^{[36
,37
]}

Jung, Tae Hoon ^{[16
]}

Caporaso, Neil ^{[1
]}

Zhao, Xueying ^{[5
]}

Huan, Zhang ^{[6
]}

Yu, Dianke ^{[11
,12
,13
,14
]}

Kim, Chang Ho ^{[16
]}

Su, Wu-Chou ^{[40
]}

Shu, Xiao-Ou ^{[15
]}

Kim, In-San ^{[17
]}

Bassig, Bryan ^{[1
]}

Chen, Yuh-Min ^{[25
,38
,39
]}

Cha, Sung Ick ^{[16
]}

Tan, Wen ^{[11
,12
,13
,14
]}

Chen, Hongyan ^{[5
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] Natl Hlth Res Inst, Div Biostat & Bioinformat, Inst Populat Hlth Sci, Zhunan, Taiwan

[3] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[4] Seoul Natl Univ, Coll Med, Inst Environm Med, Seoul, South Korea

[5] Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, State Key Lab Genet Engn,Sch Life Sci, Shanghai 200433, Peoples R China

[6] Tianjin Med Univ, Canc Hosp & Inst, Dept Epidemiol & Biostat, Tianjin 300060, Peoples R China

[7] Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan

[8] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[9] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan

[10] China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang 110001, Peoples R China

[11] Peking Union Med Coll, Beijing 100021, Peoples R China

[12] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol, Beijing 100730, Peoples R China

[13] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Carcinogenesis, Beijing 100730, Peoples R China

[14] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China

[15] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med,Vanderbilt Epidemiol Ctr,Inst Med & Publ, Nashville, TN 37212 USA

[16] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Taegu, South Korea

[17] Kyungpook Natl Univ, Sch Med, Dept Biochem, Taegu, South Korea

[18] Korea Univ, Genom Res Ctr Lung & Breast Ovarian Canc, Anam Hosp, Seoul, South Korea

[19] Korea Univ, Coll Med, Div Brain, Dept Internal Med, Seoul 136705, South Korea

[20] Korea Univ, Coll Med, Div Oncol Hematol, Dept Internal Med, Seoul 136705, South Korea

[21] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore

[22] Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan

[23] Natl Chung Hsing Univ, Inst Biomed Sci, Taichung 40227, Taiwan

[24] China Med Univ, Sch Med, Taichung, Taiwan

[25] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[26] NCI, Dept Hlth & Human Serv, Core Genotyping Facil,NIH, Adv Technol Program,Sci Applicat Int Corp Frederi, Frederick, MD USA

[27] Chang Gung Mem Hosp, Dept Pulm & Crit Care, Chiayi, Taiwan

[28] Chang Gung Univ, Dept Resp Care, Tao Yuan, Taiwan

[29] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea

[30] Seoul Natl Univ Hosp, Dept Thorac & Cardiovasc Surg, Clin Res Inst, Seoul 110744, South Korea

[31] Seoul Natl Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Seoul, South Korea

[32] Seoul Natl Univ, Bundang Hosp, Dept Thorac & Cardiovasc Surg, Geongi Do, South Korea

[33] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[34] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan

[35] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[36] Kaohsiung Med Univ, Sch Med, Kaohsiung, Taiwan

[37] Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan

[38] Natl Cheng Kung Univ, Coll Med, Tainan 70101, Taiwan

[39] Taipei Vet Gen Hosp, Chest Dept, Taipei, Taiwan

[40] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

[41] Inha Univ, Coll Med, Dept Internal Med, Inchon, South Korea

[42] China Med Univ Hosp, Ctr Canc, Taipei, Taiwan

来源：

HUMAN GENETICS | 2012年 / 131卷 / 07期

关键词：

COAL COMBUSTION EMISSIONS; GENOME-WIDE ASSOCIATION; INDOOR AIR-POLLUTION; CANCER RISK; SUSCEPTIBILITY LOCUS; CHINESE WOMEN; XUAN-WEI; POLYMORPHISMS; POPULATIONS; METAANALYSIS;

D O I：

10.1007/s00439-012-1144-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 x 10(-12)); however, this association did not achieve genome-wide significance (p a parts per thousand currency sign 10(-7)) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 x 10(-8); allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.

引用

页码：1197 / 1203

页数：7

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