6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

被引：116

作者：

Isa, Yasuka ^{[1
]}

Miyakawa, Yuri ^{[1
]}

Yanagisawa, Masayoshi ^{[1
]}

Goto, Tsuyoshi ^{[2
]}

Kang, Min-Sook ^{[2
]}

Kawada, Teruo ^{[2
]}

Morimitsu, Yasujiro ^{[3
]}

Kubota, Kikue ^{[3
]}

Tsuda, Takanori ^{[1
]}

机构：

[1] Chubu Univ, Coll Biosci & Biotechnol, Aichi 4878501, Japan

[2] Kyoto Univ, Grad Sch Agr, Kyoto 6100011, Japan

[3] Ochanomizu Univ, Fac Human Life & Environm Sci, Tokyo 1128610, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 03期

关键词：

ginger; adipocyte; adiponectin; diabetes; obesity; peroxisome proliferator-activated receptor; mitogen-activated protein kinase;

D O I：

10.1016/j.bbrc.2008.06.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-alpha (TNF-alpha) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPAR gamma agonist with its inhibitory mechanism due to the PPAR gamma transactivation, and (2) 6G is not a PPAR gamma agonist, but it is an effective inhibitor of TNF-a induced c-Jun-NH2-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：429 / 434

页数：6

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