Effect of Left Ventricular Dyssynchrony on Cardiac Sympathetic Activity in Heart Failure Patients With Wide QRS Duration

被引:30
作者
Tanaka, Hidekazu [1 ]
Tatsumi, Kazuhiro [1 ]
Fujiwara, Sei [1 ]
Tsuji, Takayuki [1 ]
Kaneko, Akihiro [1 ]
Ryo, Keiko [1 ]
Fukuda, Yuko [1 ]
Matsumoto, Kensuke [1 ]
Shigeru, Mayumi [1 ]
Yoshida, Akihiro [1 ]
Kawai, Hiroya [1 ]
Hirata, Ken-ichi [1 ]
机构
[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
关键词
Asynchrony; Cardiac resynchronization therapy; Echocardiography; Heart failure; TRACKING RADIAL STRAIN; RESYNCHRONIZATION THERAPY; SPECKLE-TRACKING; DILATED CARDIOMYOPATHY; PROGNOSTIC VALUE; NERVE ACTIVITY; SCAR BURDEN; PREDICTION; RISK; ECHOCARDIOGRAPHY;
D O I
10.1253/circj.CJ-11-0752
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Dyssynchrony has various detrimental effects on cardiac function, but its effect on cardiac sympathetic activity is not fully understood. Methods and Results: We studied 50 heart failure patients who underwent cardiac resynchronization therapy (CRT). Cardiac sympathetic activity was assessed by I-123-metaiodobenzylguanidine (I-123-MIBG) scintigraphy as the delayed heart-to-mediastinum ratio (H/M ratio). Echocardiography was performed before and 7 months after CRT, and response was defined as a >= 15% decrease in end-systolic volume. Dyssynchrony was determined by the time difference between the anteroseptal-to-posterior wall using speckle-tracking radial strain (>= 130 ms predefined as significant). H/M ratio in patients with dyssynchrony was less than that in patients without dyssynchrony (1.62 +/- 0.31 vs. 1.82 +/- 0.36, P<0.05), even though ejection fraction was not significantly different (24 +/- 6% vs. 25 +/- 7%). Patients with dyssynchrony and H/M ratio >= 1.6 had a higher frequency of response to CRT (94%) and favorable long-term outcome over 3.0 years. In contrast, patients without dyssynchrony and H/M ratio <1.6 were more likely to show a lower frequency of response to CRT (0%) and unfavorable long-term outcome after CRT. Conclusions: Dyssynchrony is associated with cardiac sympathetic activity, and I-123-MIBG scintigraphy may be valuable for predicting the response to CRT. (Circ J 2012; 76: 382-389)
引用
收藏
页码:382 / 389
页数:8
相关论文
共 28 条
  • [21] Cardiac Resynchronization Therapy - Refocus on the Electrical Substrate
    Strik, Marc
    Ploux, Sylvain
    Vernooy, Kevin
    Prinzen, Frits W.
    [J]. CIRCULATION JOURNAL, 2011, 75 (06) : 1297 - 1304
  • [22] Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy
    Suffoletto, MS
    Dohi, K
    Cannesson, M
    Saba, S
    Gorcsan, J
    [J]. CIRCULATION, 2006, 113 (07) : 960 - 968
  • [23] Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
    Sutton, MGS
    Plappert, T
    Abraham, WT
    Smith, AL
    DeLurgio, DB
    Leon, AR
    Loh, E
    Kocovic, DZ
    Fisher, WG
    Ellestad, M
    Messenger, J
    Kruger, K
    Hilpisch, KE
    Hill, MRS
    [J]. CIRCULATION, 2003, 107 (15) : 1985 - 1990
  • [24] Dyssynchrony by speckle-tracking echocardiography and response to cardiac resynchronization therapy: results of the Speckle Tracking and Resynchronization (STAR) study
    Tanaka, Hidekazu
    Nesser, Hans-Joachim
    Buck, Thomas
    Oyenuga, Olusegun
    Janosi, Rolf Alexander
    Winter, Siegmund
    Saba, Samir
    Gorcsan, John, III
    [J]. EUROPEAN HEART JOURNAL, 2010, 31 (14) : 1690 - 1700
  • [25] Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing
    Tops, Laurens F.
    Suffoletto, Matthew S.
    Bleeker, Gabe B.
    Boersma, Eric
    van der Wall, Ernst E.
    Gorcsan, John, III
    Schalij, Martin J.
    Bax, Jeroen J.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (12) : 1180 - 1188
  • [26] Effect of Atorvastatin vs. Rosuvastatin on Cardiac Sympathetic Nerve Activity in Non-Diabetic Patients With Dilated Cardiomyopathy
    Tsutamoto, Takayoshi
    Sakai, Hiroshi
    Ibe, Kunihiro
    Yamaji, Masayuki
    Kawahara, Chiho
    Nakae, Ichiro
    Fujii, Masanori
    Yamamoto, Takashi
    Horie, Minoru
    [J]. CIRCULATION JOURNAL, 2011, 75 (09) : 2160 - 2166
  • [27] Wakabayashi T, 2001, J NUCL MED, V42, P1757
  • [28] Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy
    Yu, CM
    Fung, JWH
    Zhang, Q
    Chan, CK
    Chan, YS
    Lin, H
    Kum, LCC
    Kong, SL
    Zhang, Y
    Sanderson, JE
    [J]. CIRCULATION, 2004, 110 (01) : 66 - 73