Functions and mechanics of dynein motor proteins

被引：390

作者：

Roberts, Anthony J. ^{[1
,2
]}

Kon, Takahide ^{[3
,4
]}

Knight, Peter J. ^{[1
]}

Sutoh, Kazuo ^{[5
]}

Burgess, Stan A. ^{[1
]}

机构：

[1] Univ Leeds, Fac Biol Sci, Sch Mol & Cellular Biol, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[3] Hosei Univ, Fac Biosci & Appl Chem, Dept Frontier Biosci, Koganei, Tokyo 1848584, Japan

[4] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[5] Waseda Univ, Fac Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 11期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 日本科学技术振兴机构;

关键词：

CYTOPLASMIC DYNEIN; MICROTUBULE-BINDING; MOLECULAR MOTORS; COILED-COIL; INTRAFLAGELLAR TRANSPORT; CONFORMATIONAL-CHANGES; KINETOCHORE DYNEIN; PROCESSIVE MOTION; CRYSTAL-STRUCTURE; ATPASE ACTIVITY;

D O I：

10.1038/nrm3667

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a wealth of biological processes, including ciliary beating, cell division and intracellular transport. The large mass and complexity of dynein motors have made elucidating their mechanisms a sizable task. Yet, through a combination of approaches, including X-ray crystallography, cryo-electron microscopy, single-molecule assays and biochemical experiments, important progress has been made towards understanding how these giant motor proteins work. From these studies, a model for the mechanochemical cycle of dynein is emerging, in which nucleotide-driven flexing motions within the AAA+ ring of dynein alter the affinity of its microtubule-binding stalk and reshape its mechanical element to generate movement.

引用

页码：713 / 726

页数：14

共 149 条

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