Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging

被引：59

作者：

Ji, Tianjiao ^{[1
]}

Zhao, Ying ^{[1
]}

Wang, Jing ^{[1
]}

Zheng, Xin ^{[1
]}

Tian, Yanhua ^{[1
]}

Zhao, Yuliang ^{[1
]}

Nie, Guangjun ^{[1
]}

机构：

[1] Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 14期

关键词：

ferritin; nanotechnology; cancer-associated fibroblasts; fibroblast activation protein-; imaging; SERINE-PROTEASE; CANCER; NANOPARTICLES; INHIBITION; STROMA; FLUORESCENCE; METASTASIS; CARCINOMA; PROMOTION; MURINE;

D O I：

10.1002/smll.201300600

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2427 / 2431

页数：5

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