Chitosan/nano-hydroxyapatite composite electret membranes enhance cell proliferation and osteoblastic expression in vitro

被引：14

作者：

Qu, Yili ^{[1
]}

Ao, Danting ^{[1
]}

Wang, Ping ^{[1
]}

Wang, Yanying ^{[2
]}

Kong, Xiangli ^{[1
]}

Man, Yi ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[2] Nankai Univ, Tianjin Stomatol Hosp, Dept Oral Implantol, Tianjin 300071, Peoples R China

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2014年 / 29卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Guided bone regeneration; chitosan; nano-hydroxyapatite; electret; osteoinduction; nano-hydroxyapatite composite; ENGINEERED VASCULAR GRAFTS; BONE REGENERATION; TISSUE; SCAFFOLDS; DEFECTS; FIELDS; VIVO; DIFFERENTIATION; POLYMER; COMPLEX;

D O I：

10.1177/0883911513513094

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chitosan/nano-hydroxyapatite membranes with negative charges were fabricated by grid-controlled constant voltage corona charging, and the charged membranes were investigated for cell biocompatibility and osteoinduction. The osteoblasts on the chitosan/nano-hydroxyapatite composite electret membranes significantly enhanced the adhesion, proliferation, and differentiation capacity compared to the uncharged group. This study not only provides evidence for the potential clinical application of our novel membranes but also could be used as a strategy for chitosan/nano-hydroxyapatite scaffolds.

引用

页码：3 / 14

页数：12

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