Antigenotoxic Effects of Curcumin and Piperine Alone or in Combination Against 7,12-Dimethylbenz(a)anthracene Induced Genotoxicity in Bone Marrow of Golden Syrian Hamsters

被引：15

作者：

Balakrishnan, Subramanian ^{[1
]}

Vellaichamy, Lakshmanan ^{[1
]}

Menon, Venugopal P. ^{[1
]}

Manoharan, Shanmugam ^{[1
]}

机构：

[1] Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India

来源：

TOXICOLOGY MECHANISMS AND METHODS | 2008年 / 18卷 / 09期

关键词：

Antioxidants; Curcumin; DMBA; Genotoxicity; Lipid Peroxidation; Piperine;

D O I：

10.1080/15376510701781520

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The present study investigates the effect of curcumin and piperine alone or in combination against 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity in the bone marrow of hamsters. The antigenotoxic effect was evaluated by analyzing the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and chromosomal aberrations. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30 mg/kg b.w). Oral pretreatment of curcumin (80 mg/kg b.w), piperine (50 mg/kg b.w), and curcumin (80 mg/kg b.w) + piperine (50 mg/kg b.w), respectively, for 5 days, significantly reduced the frequency of MnPCEs and the percentage of chromosomal aberrations in the bone marrow of hamsters. The results suggest that cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.

引用

页码：691 / 696

页数：6

共 22 条

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