Exploiting or overcoming the dome trap for enhanced oral immunization and drug delivery

被引：35
作者：
Qi, Jianping [1 ,2 ]
Zhuang, Jie [3 ]
Lv, Yongjiu [1 ,2 ]
Lu, Yi [1 ,2 ]
Wu, Wei [1 ,2 ]
机构：
[1] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, MOE, Shanghai 201203, Peoples R China
[2] Fudan Univ, Sch Pharm, PLA, Shanghai 201203, Peoples R China
[3] Shanghai Univ Med & Hlth Sci, Sch Pharm, Nanotechnol & Hlth Res Inst, Shanghai 201318, Peoples R China
来源：
JOURNAL OF CONTROLLED RELEASE | 2018年 / 275卷
基金：
中国国家自然科学基金;
关键词：
Dome trap; Oral; Immunization; Drug delivery; M cells; Endocytosis; Lymphatics; VIRUS-LIKE PARTICLES; SOLID LIPID NANOPARTICLES; PATCH M-CELLS; TRIMETHYL CHITOSAN NANOPARTICLES; MODIFIED INSULIN-LIPOSOMES; MUCOSAL IMMUNE-RESPONSE; LACTIC-ACID BACTERIA; EPITHELIAL M-CELLS; TARGETING M-CELLS; PEYERS-PATCHES;
D O I：
10.1016/j.jconrel.2018.02.021
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The microfold cells (M cells) residing in the outmost follicle-associated epithelia (FAE) of Peyer's patches capture foreign particles and hand over to sub-FAE lymphatics, where the particles are retained and disposed subsequently. A concept of "dome trap" is proposed to highlight the significance of this mechanism. For oral immunization, it is better to exploit the entrapment capacity to maximize immune response, whereas for drug delivery it is better to overcome the dome trap to transport drugs into the systemic circulation. By optimizing the size, shape, surface charges and surface properties of particles, either oral immunization or drug delivery can be potentially enhanced.
引用
收藏
页码：92 / 106
页数：15
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