New Preparation of TMPZnCl LiCl by Zn Insertion into TMPCl. Application to the Functionalization of Dibromodiazines

被引：33
作者：
Unsinn, Andreas [1 ]
Ford, Mark J. [2 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
[2] Bayer CropSci AG, D-65926 Frankfurt, Germany
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 05期
基金：
欧洲研究理事会;
关键词：
NICKEL-CATALYZED REACTION; DIRECTED ZINCATION; METALATION; ZINC; ARYL; PYRAZINES; PYRIDINES; DIAZINES; COPPER; ALKENYLALANES;
D O I：
10.1021/ol400248e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical zinc insertion starting from cheap commercial zinc powder and TMPCI (1-chloro-2,2,6,6-tetramethylpiperidine) allows a fast and efficient synthesis of the zinc base TMPZnCl . LiCl under mild conditions in high yields. This base is kinetically highly active and was used for the regio- and chemoselective functionalization of dibromodiazines (pyridazines and pyrazines).
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收藏
页码：1128 / 1131
页数：4
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