Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate

被引：34

作者：

Milenkovic, Milica ^{[1
]}

Bacchi, Alessia ^{[2
]}

Cantoni, Giulia ^{[2
]}

Radulovic, Sinisa ^{[3
]}

Gligorijevic, Nevenka ^{[3
]}

Arandelovic, Sandra ^{[3
]}

Sladic, Dusan ^{[1
]}

Vujcic, Miroslava ^{[4
]}

Mitic, Dragana ^{[1
]}

Andelkovic, Katarina ^{[1
]}

机构：

[1] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia

[2] Univ Parma, Dipartimento Chim Gen & Inorgan, I-43100 Parma, Italy

[3] Inst Oncol & Radiol Serbia, Dept Expt Oncol, Lab Expt Pharmacol, Belgrade, Serbia

[4] Univ Belgrade, Inst Chem Technol & Met, Belgrade 11000, Serbia

来源：

INORGANICA CHIMICA ACTA | 2013年 / 395卷

关键词：

Cobalt(III) complex; X-ray; Antitumor activity; Antimicrobial activity; DNA binding; ASYMMETRIC CONJUGATE ADDITIONS; PALLADIUM(II) COMPLEXES; CYTOTOXIC ACTIVITY; CRYSTAL-STRUCTURE; DNA-BINDING; LIGANDS; EFFICIENT; HYDROGENATION; PD(II); PT(II);

D O I：

10.1016/j.ica.2012.09.043

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA. (C) 2012 Elsevier B. V. All rights reserved.

引用

页码：33 / 43

页数：11

共 42 条

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