Facile synthesis and light-induced antibacterial activity of ketoprofen functionalized bacterial cellulose membranes

被引:17
作者
Sun, Bianjing [1 ]
Zhang, Yuntian [1 ]
Li, Wenping [1 ]
Xu, Xuran [1 ]
Zhang, Heng [1 ]
Zhao, Yuxiang [1 ]
Lin, Jianbin [1 ]
Sun, Dongping [1 ]
机构
[1] Nanjing Univ Sci & Technol, Chemicobiol & Funct Mat Inst, Xiao Ling Wei 200, Nanjing 210094, Jiangsu, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
Bacterial cellulose; Ketoprofen; Light-induced antibacterial; Reactive oxygen species; DRESSING IN-VITRO; PHOTOCATALYTIC DEGRADATION; GRAPHENE OXIDE; FABRICATION; SURFACE; FILMS; ZNO; UV; NANOCELLULOSE; COMPOSITE;
D O I
10.1016/j.colsurfa.2019.01.051
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Bacterial cellulose (BC) has already attracted tremendous interests from researchers especially those working in the area of functional nanomaterials. In this work, the chemical grafting of BC with ketoprofen (KP) was performed through eco-friendly and simple SolReact method. Surface functionalization of BC was confirmed by FTIR, XRD, XPS, TG, SEM, and TEM. Meanwhile, the stress-strain and water contact angle were also measured simultaneously. The results showed that surface functionalization was achieved under the mild reaction condition. The three-dimensional (3D) microstructure and crystalline structure of BC were maintained without being destroyed. The thermal stability of BC-KP was improved while retaining hydrophilic property and mechanical property. The photochemical property of BC-KP showed that the ROS generation was positively correlated with the time of light irradiation. The results of antibacterial tests on E.coli and S.aureus showed that the BC-KP possessed best antibacterial performance after 30 min UVA light irradiation, reaching to 72.7% and 81.6%, respectively. SEM studies displayed the cell morphology changed and membrane damaged resulting from the ROS produced under the light irradiation, which was a potential approach to prevent the bacteria resistance to conventional antibiotics. The antibacterial BC-based membranes grafting with photodynamic antimicrobial agents may be utilized as an efficient healthcare product for prevention of infectious disease.
引用
收藏
页码:231 / 238
页数:8
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