A practical, efficient synthesis of 1,1-dioxo-hexahydro-1λ6-thiopyran-4-carbaldehyde

被引：16

作者：

Bio, Matthew M. ^{[1
]}

Hansen, Karl B. ^{[1
]}

Gipson, John ^{[1
]}

机构：

[1] Amgen Inc, Chem Proc Res & Dev, Cambridge, MA 02139 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2008年 / 12卷 / 05期

关键词：

D O I：

10.1021/op800108s

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical, efficient, and scalable procedure for the preparation of 1,1-dioxo-hexahydro-1 lambda(6)-thiopyran-4-carbaldehyde is reported. Synthesis of this aldehyde was complicated by high aqueous solubility of the product and the intermediates. The isolation and purification of the aldehyde was accomplished by conversion to the crystalline bisulfite adduct.

引用

页码：892 / 895

页数：4

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