Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma

被引：9

作者：

Chang, Hyun ^{[1
]}

Lee, Yun-Gyoo ^{[2
]}

Ko, Yoon Ho ^{[3
]}

Cho, Jang Ho ^{[4
]}

Choi, Jong-Kwon ^{[5
]}

Park, Keon Uk ^{[6
]}

Kang, Eun Joo ^{[7
]}

Lee, Keun-Wook ^{[8
]}

Lim, Sun Min ^{[9
]}

Kim, Jin-Soo ^{[10
]}

Lee, Hyun Woo ^{[11
]}

Kim, Min Kyoung ^{[12
]}

Hwang, In Gyu ^{[13
]}

Kim, Sangwoo ^{[14
,15
]}

Nam, Byung-Ho ^{[16
]}

Kim, Hye Ryun ^{[9
]}

机构：

[1] Catholic Kwandong Univ, Int St Marys Hosp, Dept Med Oncol, Coll Med, Incheon 22711, South Korea

[2] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Hematol & Med Oncol,Sch Med, Seoul 03181, South Korea

[3] Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med,Div Oncol, Seoul 03312, South Korea

[4] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med,Div Oncol, Incheon 21431, South Korea

[5] Konyang Univ Hosp, Dept Internal Med, Div Hematol & Med Oncol, Daejeon 35365, South Korea

[6] Keimyung Univ, Dept Internal Med, Div Hematol Oncol, Dongsan Hosp, Daegu 51448, South Korea

[7] Korea Univ, Dept Internal Med, Div Oncol Hematol, Coll Med, Seoul 02841, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam 13620, South Korea

[9] Yonsei Univ, Yonsei Canc Ctr, Dept Internal Med, Div Med Oncol,Coll Med, Seoul 03722, South Korea

[10] Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul 07061, South Korea

[11] Ajou Univ, Dept Hematol Oncol, Sch Med, Suwon 16499, South Korea

[12] Yeungnam Univ, Dept Internal Med, Div Hematol Oncol, Coll Med, Daegu 42415, South Korea

[13] Chung Ang Univ, Chung Ang Univ Hosp, Dept Internal Med, Div Hematol Oncol,Coll Med, Seoul 06973, South Korea

[14] Yonsei Univ, Dept Biomed Syst Informat, Coll Med, Seoul 03722, South Korea

[15] Yonsei Univ, Brain Korea 21 Plus Project Med Sci, Coll Med, Seoul 03722, South Korea

[16] Inst Adv Clin & Biomed Res, HERINGS, Seoul 08378, South Korea

来源：

CANCERS | 2020年 / 12卷 / 07期

关键词：

mRNA expression; prognosis; immune cell; head and neck cancer; GENE-EXPRESSION; CANCER; METASTASIS; RECURRENT; PATHS; MODEL;

D O I：

10.3390/cancers12071777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250).CD200R1was identified as an independent prognostic factor and validated in GEO and TCGA database.CD2000R1mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover,CD200R1was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated withCD200R1expression. Samples with higherCD200R1expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy.

引用

页码：1 / 14

页数：14

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