Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

被引：22

作者：

Aziz, Jazli ^{[1
]}

Abu Kassim, Noor Lide ^{[2
]}

Abu Kasim, Noor Hayaty ^{[3
]}

Haque, Nazmul ^{[3
]}

Rahman, Mohammad Tariqur ^{[1
]}

机构：

[1] Int Islamic Univ Malaysia, Fac Sci, Bandar Indera Mahkota 25200, Kuantan, Malaysia

[2] Int Islamic Univ Malaysia, Fac Dent, Bandar Indera Mahkota 25200, Kuantan, Malaysia

[3] Univ Malaya, Fac Dent, Dept Restorat Dent, Kuala Lumpur 50603, Malaysia

来源：

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2015年 / 15卷

关键词：

Dengue fever; Megakaryopoiesis; Thrombocytes; Interleukin-6; Stem cell Factor; HUMAN-FIBROBLASTS; INTERLEUKIN-6; EXPRESSION; PROLIFERATION; INDUCTION; EXTRACTS; INCREASE; LATEX; GENE;

D O I：

10.1186/s12906-015-0749-6

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background: Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction Methods: In vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF) Results: In vitro scratch gap closure was significantly faster (p < .05) in SHED culture treated with UPJ. IL-6 concentration was significantly increased (p < .05) in SHED and PBL culture supernatant when treated with UPJ. SCF synthesis in SHED culture was also significantly increased (p < .05) when treated with UPJ Conclusion: In vitro upregulated synthesis of IL-6 and SCF both in PBL and SHED reveals the potential mechanism of unripe papaya to induce thrombopoietic cytokines synthesis in cells of hematopoietic and mesenchymal origin.

引用

页数：8

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