Peptide nanotube composed of cyclic tetra-ß-peptide having polydiacetylene

被引:17
|
作者
Ishihara, Yusuke [1 ]
Kimura, Shunsaku [1 ]
机构
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan
关键词
cyclic ss-peptide; self-assembly; peptide nanotube; polydiacetylene; photopolymerization; ORGANIC ELECTRONICS; BETA-PEPTIDE; THERMOCHROMISM; FLUORESCENCE; AMPHIPHILES; TRANSISTOR; RESOLUTION; POLYMERS; MOLECULE; CRYSTAL;
D O I
10.1002/bip.22029
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A cyclic tetra-beta-peptide composed of three beta-alanine residues and a L-beta-homolysine residue having 10,12-pentacosadiynoic amide at the side chain was synthesized. The cyclic tetra-beta-peptide formed peptide nanotubes in CDCl3. The diacetylene units along the peptide nanotubes were polymerized by UV irradiation to obtain peptide nanotubes with polydiacetylene along the nanotube. TEM and AFM observations of the polymerized cyclic tetra-beta-peptides confirmed that the peptide nanotube structure was preserved after polymerization. (C) 2011 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 155160, 2012.
引用
收藏
页码:155 / 160
页数:6
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