Efficient synthesis of spiro diheterocycles via multi-component dicyclization reaction

被引：4
作者：
Wang, Lingfeng [1 ,2 ,3 ]
Zhao, Peng [2 ,3 ]
Li, Song [2 ,3 ]
Ma, Yongmin [2 ,3 ]
Zhang, Pengfei [1 ]
Xu, Weiming [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Peoples R China
[2] Taizhou Univ, Inst Adv Studies, Jiaojiang 318000, Zhejiang, Peoples R China
[3] Taizhou Univ, Sch Pharmaceut Sci, Jiaojiang 318000, Zhejiang, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 43期
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; STRUCTURE REVISION; CYCLOADDITION; DERIVATIVES;
D O I：
10.1039/d2ob01368a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile synthetic protocol for the preparation of spiro diheterocycles from easily available 2 '-aminoacetophenones, isocyanates and 1,4-benzoquinones or quinone monoimines under mild conditions has been developed. This multi-component transformation is characterized by efficient construction of two heterocycles and one valuable quaternary carbon in one pot via an in situ cyclization-respiroannulation strategy. Moreover, this reaction showed a broad substrate scope, and generated diverse five-membered oxaspiros.
引用
收藏
页码：8461 / 8464
页数：4
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