The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

被引：209

作者：

Lembo, PMC ^{[1
]}

Grazzini, E ^{[1
]}

Cao, J ^{[1
]}

Hubatsch, DA ^{[1
]}

Pelletier, M ^{[1
]}

Hoffert, C ^{[1
]}

St-Onge, S ^{[1
]}

Pou, C ^{[1
]}

Labrecque, J ^{[1
]}

Groblewski, T ^{[1
]}

O'Donnell, D ^{[1
]}

Payza, K ^{[1
]}

Ahmad, S ^{[1
]}

Walker, P ^{[1
]}

机构：

[1] AstraZeneca R&D, Montreal, PQ H4S 1ZP, Canada

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 05期

关键词：

D O I：

10.1038/12978

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we identify MCH as the ligand for the orphan receptor SLC-1. The rat SLC-1 is activated by nanomolar concentrations of MCH and is coupled to the G protein G alpha(i/o). The pattern of SLC-1 messenger RNA expression coincides with the distribution of MCH-containing nerve terminals and is consistent with the known central effects of MCH, Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies.

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页码：267 / 271

页数：5

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