SATB2 is a Novel Marker of Osteoblastic Differentiation and Colorectal Adenocarcinoma

被引：40

作者：

Ordonez, Nelson G. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2014年 / 21卷 / 01期

关键词：

SATB2; immunohistochemistry; bone tumors; osteosarcoma; colorectal adenocarcinoma; DIAGNOSTIC MARKER; OSTEONECTIN IMMUNOREACTIVITY; PULMONARY ADENOCARCINOMAS; METASTATIC CARCINOMAS; CYTOSKELETAL PROTEIN; TRANSCRIPTION FACTOR; SKELETAL DEVELOPMENT; CYTOKERATINS; EXPRESSION; VILLIN;

D O I：

10.1097/PAP.0000000000000001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

SATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator that is involved in osteoblastic differentiation and is also expressed in the glandular epithelial cells of the lower gastrointestinal tract. Recent studies have shown that, because of its relative specificity for osteoblastic differentiation, SATB2 immunostaining could potentially be a useful adjunct for assisting in the differential diagnosis of both benign and malignant osteogenic tumors. In addition, because SATB2 is also a highly sensitive and specific marker for colorectal adenocarcinomas, it could also serve as a complementary marker in the differential diagnosis of a carcinoma of unknown primary origin.

引用

页码：63 / 67

页数：5

共 60 条

[1] Foamy gland pattern of pancreatic ductal adenocarcinoma - A deceptively benign-appearing variant [J].

Adsay, V ;

Logani, S ;

Sarkar, F ;

Crissman, J ;

Vaitkevicius, V .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2000, 24 (04) :493-504

[2]

BACCHI CE, 1991, LAB INVEST, V64, P418

[3] CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs [J].

Barbareschi, M ;

Murer, B ;

Colby, TV ;

Chilosi, M ;

Macri, E ;

Loda, M ;

Doglioni, C .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (02) :141-149

[4] CDX-2 homeobox gene product expression in neuroendocrine tumors - Its role as a marker of intestinal neuroendocrine tumors [J].

Barbareschi, M ;

Roldo, C ;

Zamboni, G ;

Capelli, P ;

Cavazza, A ;

Macri, E ;

Cangi, MG ;

Chilosi, M ;

Doglioni, C .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2004, 28 (09) :1169-1176

[5]

Berezowski K, 1996, MODERN PATHOL, V9, P426

[6] SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury [J].

Bradshaw, AD ;

Sage, EH .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (09) :1049-1054

[7]

Brekken Rolf A., 2001, Matrix Biology, V19, P816

[8] Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex [J].

Britanova, Olga ;

de Juan Romero, Camino ;

Cheung, Amanda ;

Kwan, Kenneth Y. ;

Schwark, Manuela ;

Gyorgy, Andrea ;

Vogel, Tanja ;

Akopov, Sergey ;

Mitkovski, Mico ;

Agoston, Denes ;

Sestan, Nenad ;

Molnar, Zoltan ;

Tarabykin, Victor .

NEURON, 2008, 57 (03) :378-392

[9] Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development [J].

Britanova, Olga ;

Depew, Michael J. ;

Schwark, Manuela ;

Thomas, Bethan L. ;

Miletich, Isabelle ;

Sharpe, Paul ;

Tarabykin, Victor .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 79 (04) :668-678

[10] Differentiation of ovarian mucinous carcinoma and metastatic colorectal adenocarcinoma by immunostaining with β-catenin [J].

Chou, YY ;

Jeng, YM ;

Kao, HL ;

Chen, TJ ;

Mao, TL ;

Lin, MC .

HISTOPATHOLOGY, 2003, 43 (02) :151-156

← 1 2 3 4 5 6 →