Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations

被引:16
|
作者
Lien, Shin-Yu A. [1 ,2 ]
Young, Lufei [3 ]
Gau, Bih-Shya [4 ]
Shiao, S. Pamela K. [3 ]
机构
[1] Chang Gung Univ, Coll Med, Sch Nursing, Taoyuan, Taiwan
[2] Chang Gung Mem Hosp, Linkou Branch, Dept Internal Med, Div Endocrinol & Metab, Taoyuan, Taiwan
[3] Augusta Univ, Coll Nursing, Augusta, GA 30912 USA
[4] Natl Taiwan Univ, Sch Nursing, Coll Med, Taipei, Taiwan
关键词
meta-analysis; meta-prediction; methylenetetrahydrofolate reductase; leukemia; air pollution; ACUTE LYMPHOBLASTIC-LEUKEMIA; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISMS; HARDY-WEINBERG EQUILIBRIUM; INFORMATION CRITERION; CHILDHOOD LEUKEMIA; C677T POLYMORPHISM; METAANALYSIS; ASSOCIATION; SUSCEPTIBILITY; BIAS;
D O I
10.18632/oncotarget.13876
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia.
引用
收藏
页码:4387 / 4398
页数:12
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