Influence of effector molecules on the CD8+ T cell response to infection

被引：80
作者：
Harty, JT
Badovinac, VP
机构：
[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[2] Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 03期
关键词：
D O I：
10.1016/S0952-7915(02)00333-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Expansion and contraction of antigen-specific CD8(+) T cells after infection or vaccination results in stable memory, Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance.
引用
收藏
页码：360 / 365
页数：6
相关论文
共 50 条
[1]   Immunological memory and protective immunity: Understanding their relation [J].
Ahmed, R ;
Gray, D .
SCIENCE, 1996, 272 (5258) :54-60
[2]  
Andersson Å, 1998, J IMMUNOL, V161, P5600
[3]   Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ [J].
Badovinac, VP ;
Tvinnereim, AR ;
Harty, JT .
SCIENCE, 2000, 290 (5495) :1354-1357
[4]  
Barchet W, 2000, EUR J IMMUNOL, V30, P1356, DOI 10.1002/(SICI)1521-4141(200005)30:5<1356::AID-IMMU1356>3.0.CO
[5]  
2-K
[6]   Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus [J].
Bartholdy, C ;
Christensen, JP ;
Wodarz, D ;
Thomsen, AR .
JOURNAL OF VIROLOGY, 2000, 74 (22) :10304-10311
[7]   Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins [J].
Bird, PI .
IMMUNOLOGY AND CELL BIOLOGY, 1999, 77 (01) :47-57
[8]   Cellular responses to interferon-gamma [J].
Boehm, U ;
Klamp, T ;
Groot, M ;
Howard, JC .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795
[9]   Coordinate regulation of complex T cell populations responding to bacterial infection [J].
Busch, DH ;
Pilip, IM ;
Vijh, S ;
Pamer, EG .
IMMUNITY, 1998, 8 (03) :353-362
[10]   Massive expansion of antigen-specific CD8+ T cells during an acute virus infection [J].
Butz, EA ;
Bevan, MJ .
IMMUNITY, 1998, 8 (02) :167-175
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