Rigid cinchona conformers in enantioselective catalytic reactions:: new cinchona-modified platinum catalysts in the Orito reaction

被引：56

作者：

Bartók, M

Felföldi, K

Szöllösi, G

Bartók, T

机构：

[1] Attila Jozsef Univ, Dept Organ Chem, H-6720 Szeged, Hungary

[2] Attila Jozsef Univ, Hungarian Acad Sci, Organ Catalysis Res Grp, H-6720 Szeged, Hungary

来源：

CATALYSIS LETTERS | 1999年 / 61卷 / 1-2期

关键词：

chiral; hydrogenation; ethyl pyruvate; ethyl benzoylformate; cinchona alkaloids; rigid conformers;

D O I：

10.1023/A:1019008519015

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The use of cinchona alkaloids (cinchonidine, cinchonine, quinine, quinidine, alpha-isocinchonine, alpha-isoquinidine, gamma-isoquinidine) in the Orito reaction (hydrogenation of ethyl pyruvate and ethyl benzoylformate) strongly supports the structure of the intermediate complex (cinchona alkaloid "anti-open" conformer-pyruvate 1 : 1 complex); in addition, so far unknown stereochemical conditions have been identified and the utilization of rigid cinchona conformers in the study of asymmetric syntheses have been generalized.

引用

页码：1 / 5

页数：5

共 28 条

[1]

[Anonymous], J CHEM SOC JPN

[2]

[Anonymous], 1995, CHIRAL REACTIONS HET

[3] Enantioselective heterogeneous catalysis .2. Examination of the formation of the individual (R) and (S) lactates in the cinchonidine modified platinum hydrogenation of pyruvate [J].