Role of hypothalamic interleukin-1β (IL-1β) in regulation of energy homeostasis by melanocortins

被引：24
作者：
Wisse, BE [1 ]
Ogimoto, K [1 ]
Schwartz, MW [1 ]
机构：
[1] Univ Washington, Harborview Med Ctr, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98104 USA
来源：
PEPTIDES | 2006年 / 27卷 / 02期
关键词：
cytokine; food intake; appetite; obesity; inflammation;
D O I：
10.1016/j.peptides.2005.08.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the current study we sought to determine whether hypothalamic IL-1 beta is regulated by melanocortin signaling and if melanocortin-induced changes in energy balance are dependent on IL-1 beta. A melanocortin agonist, MTII, increased hypothalamic IL-1 beta mRNA levels by two-fold, whereas a melanocortin antagonist, SHU9119, blunted lipopolysaccharide (LPS)-mediated increase of hypothalamic IL-1 beta content. Pharmacological or genetic disruption of IL-1 receptor signaling prevented MTII-mediated reductions in locomotor activity, but did not reduce MTII-induced anorexia. These data suggest a potential role for central melano-cortins in mediating the decrease of ambulation characteristic of the 'sickness' response. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：265 / 273
页数：9
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