FGF-23 removal is improved by on-line high-efficiency hemodiafiltration compared to conventional high flux hemodialysis

被引：38

作者：

Patrier, Laure ^{[1
,2
,3
]}

Dupuy, Anne-Marie ^{[1
]}

Vallee, Alexandre Granger ^{[2
]}

Chalabi, Lotfi ^{[4
]}

Morena, Marion ^{[1
,3
,5
]}

Canaud, Bernard ^{[2
,3
,4
,5
]}

Cristol, Jean-Paul ^{[1
,3
]}

机构：

[1] Montpellier Univ Hosp, Biochem Lab, Montpellier, France

[2] Montpellier Univ Hosp, Dept Nephrol Dialysis & Intens Care, Montpellier, France

[3] Nutripass, Mixed Res Unit 204, Montpellier, France

[4] Jacques Mirouze Clin, Assoc Installat & Domicile Epurat Renales, Montpellier, France

[5] Montpellier Univ Hosp, Dialysis Res & Training Inst, Montpellier, France

来源：

JOURNAL OF NEPHROLOGY | 2013年 / 26卷 / 02期

关键词：

Hemodialysis; Hemodiafiltration; FGF-23; FGF23; FIBROBLAST GROWTH FACTOR-23; CHRONIC KIDNEY-DISEASE; FAMILIAL TUMORAL CALCINOSIS; SECONDARY HYPERPARATHYROIDISM; DIALYSIS PATIENTS; BETA-2-MICROGLOBULIN LEVELS; PHOSPHATE HOMEOSTASIS; RENAL-FUNCTION; LEVELS PREDICT; GALNT3; GENE;

D O I：

10.5301/jn.5000150

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Reducing circulating levels of fibroblast growth factor-23 (FGF-23) in patients on renal replacement therapy (RRT) could appear as an appealing approach for cardiovascular events prevention. The purpose of our study was to compare the clearance of FGF-23 between high flux hemodialysis (HD) and online hemodiafiltration (OL-HDF) procedures. Methods: Fifty-three patients were included in the HD group while 32 patients were included in the OL-HDF group. Serum pre- and post-dialysis FGF-23 levels were measured using a 2nd generation Human FGF-23 (C-Term) ELISA kit. Results: Mean FGF-23 reduction rates were significantly higher in OL-HDF (55.7 +/- 25.2%) versus HD (36.2 +/- 28.6%) groups (P=.0001), as were calculated FGF-23 clearances (P=.015) and Kt/V-FGF-23 (P=.001). Overall, post-treatment FGF-23 levels were significantly lower than pre-treatment values in both groups (P<.01). Conclusions: OL-HDF achieves higher FGF-23 removal over high flux HD.

引用

页码：342 / 349

页数：8

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