Incident pulmonary arterial hypertension associated with Bosutinib

被引：9

作者：

Yo, Shaun ^{[1
]}

Thenganatt, John ^{[1
]}

Lipton, Jeffrey ^{[2
]}

Granton, John ^{[1
]}

机构：

[1] Univ Toronto, Dept Med, Div Respirol, 585 Univ Ave, Toronto, ON M5G 2N2, Canada

[2] Princess Margaret Canc Ctr, Toronto, ON, Canada

来源：

PULMONARY CIRCULATION | 2020年 / 10卷 / 03期

关键词：

drug-induced pulmonary hypertension; tyrosine kinase inhibitors; chronic myeloid leukemia; Macitentan; TYROSINE KINASE; DETERIORATION; THERAPY;

D O I：

10.1177/2045894020936913

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug-induced pulmonary arterial hypertension. There have been case reports linking Bosutinib with deterioration of pre-existing pulmonary arterial hypertension. Here, we present a case of a 37-year-old woman with chronic myeloid leukemia treated with Bosutinib who was diagnosed with pulmonary arterial hypertension. Prior to Bosutinib, she had received Dasatinib without documented cardiopulmonary toxicity. Withdrawal of Bosutinib led to partial reversal of pulmonary arterial hypertension, and with the addition of pulmonary arterial hypertension-targeted treatment, there was near normalization of hemodynamics.

引用

页数：4

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