BODIPYs to the rescue: Potential applications in photodynamic inactivation

被引：138

作者：

Durantini, Andres M. ^{[1
]}

Heredia, Daniel A. ^{[1
]}

Durantini, Javier E. ^{[1
]}

Durantini, Edgardo N. ^{[1
]}

机构：

[1] Univ Nacl Rio Cuarto, Fac Ciencias Exactas Fis Quim & Nat, Dept Quim, Ruta Nacl 36 Km 601,X5804BYA, Cordoba, Argentina

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 144卷

关键词：

BODIPY; Photosensitizer; Photoinactivation; Singlet oxygen; Microorganisms; TRIPLET EXCITED-STATE; CANDIDA-ALBICANS; SINGLET OXYGEN; BORON DIPYRROMETHENE; DIFLUORIDE BODIPY; DRUG DISCOVERY; DYES; FLUORESCENT; PHOTOINACTIVATION; PHOTOSENSITIZER;

D O I：

10.1016/j.ejmech.2017.12.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives have been proposed in several potential biomedical applications. BODIPYs absorb strongly in blue-green region with high fluorescence emission, properties that convert them in effective fluorophores in the field of biological labeling. However, BODIPY structures can be conveniently modified by heavy atoms substitution to obtain photosensitizers with applications in photodynamic therapy. Also, external heavy atoms effect can be used to increase the photodynamic activity of these compounds, In recent years, BODIPYs have been proposed as phototherapeutic agents for the photodynamic inactivation of microorganisms. Therefore, BODIPY structures need to be optimized to produce an efficient photocytotoxic activity. In this way, amphiphilic cationic BODIPYs can selectively bind to microbial cells, inducing an effective photokilling of pathogenic microbial cells. This review summarizes the attributes of BODIPY derivatives for applications as antimicrobial photosensitizing agents. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：651 / 661

页数：11

共 92 条

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