Subarachnoid Hemorrhage: a Review of Experimental Studies on the Microcirculation and the Neurovascular Unit

被引：119

作者：

Tso, Michael K. ^{[1
,2
]}

Macdonald, R. Loch ^{[3
,4
]}

机构：

[1] St Michaels Hosp, Div Neurosurg, Toronto, ON M5B 1W8, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[3] St Michaels Hosp, Div Neurosurg, Labatt Family Ctr Excellence Brain Injury & Traum, Keenan Res Ctr,Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

[4] Univ Toronto, Dept Surg, Toronto, ON, Canada

来源：

TRANSLATIONAL STROKE RESEARCH | 2014年 / 5卷 / 02期

基金：

加拿大健康研究院;

关键词：

Subarachnoid hemorrhage; Neurovascular unit; Microcirculation; Animal model; Arteriole; Pathophysiology; BLOOD-BRAIN-BARRIER; REDUCES BEHAVIORAL DEFICITS; MICROVASCULAR BASAL LAMINA; DELAYED CEREBRAL-ISCHEMIA; PERMEABILITY CHANGES; RAT MODEL; PIAL MICROCIRCULATION; RECEPTOR ANTAGONIST; VASCULAR INJURY; DOUBLE-BLIND;

D O I：

10.1007/s12975-014-0323-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increased microthrombi, and inversion of neurovascular coupling. This focused review looks at the current state of knowledge regarding the changes that occur in the microcirculation and the neurovascular unit after SAH.

引用

页码：174 / 189

页数：16

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