Use of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol as an independent biomarker to classify smoking status

被引：3
作者：
Jain, Ram B.
机构：
[1] Dacula, GA
来源：
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2015年 / 97卷 / 10期
关键词：
specificity; sensitivity; ROC curves; smoking; NNAL; SERUM COTININE; TOBACCO; SMOKERS; NITROSAMINES; CARCINOGEN; NICOTINE;
D O I：
10.1080/02772248.2015.1093130
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Biomarkers of exposure to tobacco smoke are needed. The objective of this study was to develop total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) as a biomarker of tobacco smoke independent of serum cotinine. Data from National Health and Nutrition Examination Survey were used to estimate cut-off points on NNAL scale to differentiate participants in various classes of smoking status. A cut-off of 13.4 pg/mL for NNAL differentiated smokers from nonsmokers with a specificity and sensitivity of 92%. NNAL can be used as an independent biomarker of exposure to tobacco smoke with high specificity and sensitivity.
引用
收藏
页码：1422 / 1438
页数：17
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