Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

被引：34

作者：

Yurttas, Leyla ^{[1
]}

Duran, Murat ^{[2
]}

Demirayak, Seref ^{[3
]}

Gencer, Hulya Karaca ^{[4
]}

Tunali, Yagmur ^{[4
]}

机构：

[1] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey

[2] Eskisehir Osmangazi Univ, Fac Sci & Letters, Dept Chem, TR-26480 Eskisehir, Turkey

[3] Medipol Univ, Sch Pharm, Dept Pharmaceut Chem, TR-34083 Istanbul, Turkey

[4] Anadolu Univ, Dept Microbiol, Fac Pharm, TR-26470 Eskisehir, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 24期

关键词：

Imidazole; Antimicrobial; Brine-Shrimp test; Anticancer; ANTIBACTERIAL; ANTITUMOR; RESISTANT;

D O I：

10.1016/j.bmcl.2013.10.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6764 / 6768

页数：5

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