Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets

被引：80
作者：
DiRienzo, Douglas B. [1 ]
机构：
[1] Quadrant Nutr LLC, Hendersonville, NC USA
来源：
NUTRITION REVIEWS | 2014年 / 72卷 / 01期
关键词：
cardiovascular health; low-density lipoprotein; probiotic; safety; therapeutic diets; REUTERI NCIMB 30242; FERMENTED MILK PRODUCT; DENSITY-LIPOPROTEIN CHOLESTEROL; PLASMA-LIPID PROFILE; LACTOBACILLUS-ACIDOPHILUS; GUT MICROBIOTA; BLOOD-LIPIDS; SERUM-LIPIDS; CONVENTIONAL YOGURT; LOWERING FOODS;
D O I：
10.1111/nure.12084
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The objectives of this article are to review clinical trials that have examined the effects of probiotics on low-density lipoprotein cholesterol (LDL-C) and to assess the potential of probiotic intake as a therapeutic lifestyle change (TLC) dietary option. Twenty-six clinical studies and two meta-analyses are reviewed. Significant LDL-C reductions were observed for four probiotic strains: LactobacillusreuteriNCIMB 30242, Enterococcusfaecium, and the combination of LactobacillusacidophilusLa5 and BifidobacteriumlactisBb12. Two synbiotics, L.acidophilusCHO-220 plus inulin and L.acidophilus plus fructo-oligosaccharides, also decreased LDL-C. Of the probiotics examined, L.reuteriNCIMB 30242 was found to best meet TLC dietary requirements by 1) significantly reducing LDL-C and total cholesterol, with robustness similar to that of existing TLC dietary options, 2) improving other coronary heart disease risk factors, such as inflammatory biomarkers, and 3) having generally recognized as safe (GRAS) status. Based on these results, the probiotic L.reuteriNCIMB 30242 is a viable candidate both for future TLC dietary studies and as a potential option for inclusion in TLC dietary recommendations. (C) 2013 International Life Sciences Institute
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页码：18 / 29
页数：12
相关论文
共 86 条
[11]   Evaluation of the effects of a new fermented milk product (Gaio) on primary hypercholesterolemia [J].
Bertolami, MC ;
Faludi, AA ;
Batlouni, M .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 1999, 53 (02) :97-101
[12]  
Branton W. B., 2010, INT J PROBIOTICS PRE, V6, P1
[13]   Scientific Opinion on the maintenance of the list of QPS microorganisms intentionally added to food or feed (2009 update) EFSA Panel on Biological Hazards (BIOHAZ) [J].
Collins, John Daniel ;
Noerrung, Birgit ;
Budka, Herbert ;
Andreoletti, Olivier ;
Buncic, Sava ;
Griffin, John ;
Hald, Tine ;
Havelaar, Arie Hendric ;
Hope, James ;
Klein, Gunter ;
McLauchlin, James ;
Messens, Winy ;
Mueller-Graf, Christine ;
Nguyen-The, Christophe ;
Luisa, Peixe ;
Maradona, Miguel Prieto ;
Ricci, Antonia ;
Sofos, John ;
Threlfall, John ;
Vagsholm, Ivar ;
Vanopdenbosch, Emmanuel .
EFSA JOURNAL, 2009, 7 (12)
[14]   Safety of D(-)-lactic acid producing bacteria in the human infant [J].
Connolly, E ;
Abrahamsson, T ;
Björkstén, B .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 41 (04) :489-492
[15]   Yoghurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels [J].
de Roos, NM ;
Schouten, G ;
Katan, MB .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 1999, 53 (04) :277-280
[16]   Probiotics, Prebiotics, and Synbiotics [J].
de Vrese, Michael ;
Schrezenmeir, J. .
FOOD BIOTECHNOLOGY, 2008, 111 :1-66
[17]  
Department of Health and Ageing Therapeutic Goods Administration, 2007, SUBST MAY US LIST ME
[18]   Beneficial Health Effects of Milk and Fermented Dairy Products [J].
Ebringer, L. ;
Ferencik, M. ;
Krajcovic, J. .
FOLIA MICROBIOLOGICA, 2008, 53 (05) :378-394
[19]   Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus [J].
Ejtahed, H. S. ;
Mohtadi-Nia, J. ;
Homayouni-Rad, A. ;
Niafar, M. ;
Asghari-Jafarabadi, M. ;
Mofid, V. ;
Akbarian-Moghari, A. .
JOURNAL OF DAIRY SCIENCE, 2011, 94 (07) :3288-3294
[20]   Influence of daily consumption of probiotic and conventional yoghurt on the plasma lipid profile in young healthy women [J].
Fabian, Elisabeth ;
Elmadfa, Ibrahim .
ANNALS OF NUTRITION AND METABOLISM, 2006, 50 (04) :387-393
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