Form IV of carbamazepine

被引：167

作者：

Lang, MD

Kampf, JW

Matzger, AJ ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Macromol Sci & Engn, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2002年 / 91卷 / 04期

关键词：

carbamazepine; polymorphism; X-ray diffraction; crystal structure; hydrogen bond;

D O I：

10.1002/jps.10093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Carbamazepine has been found to crystallize as a new polymorph that is stable at room temperature. We report the crystal structure of this C-centered monoclinic form (space group C2/c, cell parameters: a = 26.609, b = 6.9269, c = 13.957, beta = 109.702), which consists of hydrogen bonded dimers with an anti-disposition. This represents the third modification of carbamazepine that has been crystallographically characterized, and the fourth for which cell parameters have been determined. Thus, it is designated as form IV of carbamazepine. Differences between the packing of the various polymorphs are discussed. (C) 2002 Wiley-Liss, Inc.

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页码：1186 / 1190

页数：5

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