Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran E and Other Targets of Interest

被引：90
作者：
Blaisdell, Thomas P. [1 ]
Morken, James P. [1 ]
机构：
[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 27期
关键词：
SECONDARY; DIBORATION; OXIDATION; ACTIVATION; RETENTION; INVERSION; ALCOHOLS; ESTERS;
D O I：
10.1021/jacs.5b05477
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A hydroxyl functional group positioned beta to a pinacol boronate can serve to direct palladium-catalyzed cross-coupling reactions. This feature can be used to control the reaction site in multiply borylated substrates and can activate boronates for reaction that would otherwise be unreactive.
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收藏
页码：8712 / 8715
页数：4
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