Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran E and Other Targets of Interest

被引：90

作者：

Blaisdell, Thomas P. ^{[1
]}

Morken, James P. ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 27期

关键词：

SECONDARY; DIBORATION; OXIDATION; ACTIVATION; RETENTION; INVERSION; ALCOHOLS; ESTERS;

D O I：

10.1021/jacs.5b05477

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hydroxyl functional group positioned beta to a pinacol boronate can serve to direct palladium-catalyzed cross-coupling reactions. This feature can be used to control the reaction site in multiply borylated substrates and can activate boronates for reaction that would otherwise be unreactive.

引用

页码：8712 / 8715

页数：4

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